Clinical trial

Exercise Training and Vitamin D Metabolism

Recruiting now · Not applicable · 1 countries · Registry ID NCT07300332

Recruiting nowNot applicableInterventional

What this study is about

The prevalence of Vitamin D deficiency is significantly higher in adults with overweight/obesity compared to those with normal body mass index (BMI). The "entrapment" of Vitamin D in adipose tissue due to impaired lipolytic stimulation and/or adipose tissue dysfunction has been proposed as the driving mechanism. Exercise training has been proposed as a promising strategy to increase mobilization of Vitamin D from adipose tissue, given its well described role in stimulating lipolysis. Indeed, a recent study revealed that participation in moderate-intensity cardiovascular type exercise over winter can mitigate the decline in 25-hydroxyvitamin D \[25(OH)D\] in adults with overweight/obesity, independent of weight loss. The aim of this study is to investigate the impact of hybrid-type high-intensity interval training over winter on vitamin D metabolism, in adults with overweight/obesity.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age35 Years to 50 Years

SexAll

Healthy volunteersAccepted

ConditionObesity & Overweight, Vitamin D

Full registry criteria

Inclusion Criteria: * BMI = 25-35 kg/m2 * Absence of musculoskeletal injuries * Absence of chronic health-related complications * Non-smokers Exclusion Criteria: * Consumption of Vitamin D supplements * Consumption of anti-inflammatory drugs, statins and/or steroids

Treatments and study arms

Exercise training

Other

Receive a balanced diet and participate in three hybrid-type high-intensity interval training sessions per week over a 12-week period

Control

Other

Receive a balanced diet but abstain from any type of exercise training

Primary outcomes

Change in 25-hydroxyvitamin D concentrationAt baseline, 6 weeks and 12 weeks

25-OH-VD will be quantitatively determined in serum

Change in plasma Vitamin D binding protein concentrationAt baseline, 6 weeks and 12 weeks

Vitamin D binding protein concentration will be determined in plasma

Change in calcium concentrationAt baseline, 6 weeks and 12 weeks

Calcium concentration will be determined in serum

Change in albumin concentrationAt baseline, 6 weeks and 12 weeks

Albumin concentration will be determined in serum

Change in aspartate aminotransferase (SGOT) concentrationAt baseline, 6 weeks and 12 weeks

SGOT concentration will be determined in serum on a Clinical Chemistry analyzer

Change in alanine aminotransferase (SGPT) concentrationAt baseline, 6 weeks and 12 weeks

SGPT concentration will be determined in serum on a Clinical Chemistry analyzer

Change in gamma-glutamyl transferase (γ-GT) concentrationAt baseline, 6 weeks and 12 weeks

γ-GT concentration will be determined in serum on a Clinical Chemistry analyzer

Study locations

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Department of Physical Education and Sport Science, University of Thessaly🇬🇷 Trikala, Karyes, Greece

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Athanasios Z Jamurtas, PhDContact

Email · Call 2431047054

Ioannis G Fatouros, PhDContact

Email · Call 2431047047

Eytychia Giouvri, BScSub Investigator