Clinical trial

Comparison of Acceleromyography and Electromyography in Obese Patients Undergoing General Anesthesia

Opening soon · Not applicable · 1 countries · Registry ID NCT07283354

Opening soonNot applicableObservational

What this study is about

The goal of this prospective observational study is to compare two different methods of monitoring muscle relaxation during anesthesia - acceleromyography (AMG) and electromyography (EMG) - in people with obesity who are having bariatric surgery with general anesthesia and the muscle relaxant rocuronium. The main question is: Which method is more accurate and precise in measuring the Train-of-Four (TOF) ratio during surgery? As part of this comparison, researchers will also note how quickly each method detects recovery of muscle function after the reversal drug sugammadex. Participants will: * Receive standard anesthesia care for bariatric surgery, including rocuronium to relax the muscles. * Have two small monitoring devices applied, one to each hand: AMG on one hand, EMG on the other. * Be monitored for muscle function during surgery and after receiving sugammadex to reverse the muscle relaxation. Researchers will also record how easy each device is to use and whether participants have any breathing problems after surgery.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 65 Years

SexAll

Healthy volunteersNot accepted

ConditionObesity

Full registry criteria

Inclusion Criteria: * Adults aged 18-65 years * Pathological obesity (Class II with comorbidities or Class III) * Scheduled for bariatric surgery under general anesthesia * Written informed consent obtained Exclusion Criteria: * Severe acute or chronic respiratory disease (e.g., asthma, COPD, severe restrictive disease) * Severe acute or recent cardiac disease (e.g., acute or recent myocardial infarction, inducible ischemia, heart failure) * End-stage hepatic or renal disease * Intolerance, allergy, or contraindication to study-related drugs * Absence of informed consent

Treatments and study arms

Neuromuscular monitoring with electromyography (EMG)

Procedure

Neuromuscular function will be assessed using an electromyography device applied to the hand. The device measures the electrical activity of muscles in response to ulnar nerve stimulation to calculate the Train-of-Four (TOF) ratio.

Neuromuscular monitoring with acceleromyography (AMG)

Procedure

Neuromuscular function will be assessed using an acceleromyography device applied to the hand. The device measures the acceleration of thumb movement in response to ulnar nerve stimulation to calculate the Train-of-Four (TOF) ratio.

Primary outcomes

Mean paired difference in TOF ratio (AMG vs EMG)Intraoperative period

Mean difference between acceleromyography (AMG) and electromyography (EMG) measurements of the Train-of-Four (TOF) ratio (unitless) obtained from paired intraoperative recordings.

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Azienda Ospedale - Università di Padova (Padua University Hospital)🇮🇹 Padova, PD, Italy

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Michele CarronContact

Email · Call +390498213090