Clinical trial
A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, and Type 2 Diabetes
Recruiting now · Phase 3 · 5 countries · Registry ID NCT07282600
Recruiting nowPhase 3Interventional
What this study is about
The main purpose of this study is to evaluate the efficacy and safety of eloralintide compared with placebo for body weight reduction in participants with overweight or obesity and type 2 diabetes. Participation in the study will last about 75 weeks.
A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.
Basic eligibility
Age18 Years to Not listed
SexAll
Healthy volunteersNot accepted
ConditionOverweight, Obesity
Full registry criteria
Inclusion Criteria: * Have type 2 diabetes * Are on stable treatment for type 2 diabetes for at least 90 days prior to screening * Have a BMI ≥ 27 kg/m2 * Have a stable body weight (\<5% body weight change) for 90 days prior to screening Exclusion Criteria: * Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed \>1 year before screening) * Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening) * Have type 1 diabetes * Have taken any of the following antihyperglycemic medications within 90 days before screening: * amylin analogs * glucagon-like peptide-1 (GLP-1) receptor agonists * glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 (GIP/GLP) receptor agonists, or * insulin * Have had within 90 days prior to screening: * heart attack * stroke * coronary artery revascularization * unstable angina, or * hospitalization due to congestive heart failure * Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure * Have taken medications or alternative remedies intended for weight loss within 90 days of screening
Treatments and study arms
Eloralintide
Drug
Administered SC
Placebo
Drug
Administered SC
Primary outcomes
Percent Change from Baseline in Body WeightBaseline, Week 64
Study locations
157 locations were listed when this page was built. The first 40 are shown.
Asociación de Beneficencia Hospital Sirio Libanés🇦🇷 Buenos Aires, Argentina
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Gustavo FrechtelPrincipal Investigator
Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada🇦🇷 Buenos Aires, Argentina
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Evelyn BlancPrincipal Investigator
Investigaciones Medicas Imoba Srl🇦🇷 Buenos Aires, Argentina
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Silvia OrioPrincipal Investigator
Stat Research S.A.🇦🇷 Buenos Aires, Argentina
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Lucas GutniskyPrincipal Investigator
Instituto Centenario🇦🇷 CABA, Argentina
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SUSANA SALZBERGPrincipal Investigator
Centro Diabetológico Dr. Waitman🇦🇷 Córdoba, Argentina
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Silvana Ernestina SolisPrincipal Investigator
Centro de Investigaciones Clínicas Baigorria🇦🇷 Granadero Baigorria, Argentina
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Maximiliano SicerPrincipal Investigator
Fundacion Estudios Clinicos🇦🇷 Rosario, Argentina
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María SchiavoniPrincipal Investigator
Instituto Médico Catamarca IMEC🇦🇷 Rosario, Argentina
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Natacha MaldonadoPrincipal Investigator
Beijing Pinggu District Hospital🇨🇳 Beijing, China
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yufeng liPrincipal Investigator
Peking University People's Hospital🇨🇳 Beijing, China
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Linong JiPrincipal Investigator
The Second Affiliated Hospital Chongqing Medical University🇨🇳 Chongqing, China
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Dongfang LiuPrincipal Investigator
The Second People's Hospital of Hefei🇨🇳 Hefei, China
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Jun YePrincipal Investigator
The First Affiliated Hospital of Henan University of Science &Technology🇨🇳 Luoyang Shi, China
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Hongwei JiangPrincipal Investigator
Jiangxi Provincial People's Hospital🇨🇳 Nanchang, China
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Zongyou ChengPrincipal Investigator
The Second Affiliated Hospital of Nanjing Medical University🇨🇳 Nanjing, China
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Yibing LuPrincipal Investigator
The Second Hospital of Tianjin Medical University🇨🇳 Tianjin, China
Yu ChenPrincipal Investigator
MUDr. Tomas Edelsberger🇨🇿 Krnov, Czechia
MUDr. Miroslav Koliba s.r.o.🇨🇿 Ostrava, Czechia
Diabet2 s.r.o., diabetologicka a interni ambulance🇨🇿 Prague, Czechia
MUDr. Jana Parkanyiova🇨🇿 Prague, Czechia
Diabetespraxis Dr. Braun🇩🇪 Berlin, Germany
Private Practice - Dr. Kai Könemann & Dr. Henrik Könemann🇩🇪 Bünde, Germany
InnoDiab Forschung Gmbh🇩🇪 Essen, Germany
Diabetes Zentrum Wilhelmsburg🇩🇪 Hamburg, Germany
Institut für Diabetesforschung GmbH Münster🇩🇪 Münster, Germany
Schwerpunktpraxis für Diabetes und Ernährungsmedizin Dr. med. Winfried Keuthage🇩🇪 Münster, Germany
RED-Institut GmbH🇩🇪 Oldenburg, Germany
Life Care Hospital and Research Centre🇮🇳 Bangalore, India
Belagavi Institute of Medical Sciences - Belagavi🇮🇳 Belgavi, India
Dr. Ram Manohar Lohia Institute of Medical Sciences🇮🇳 Lucknow, India
All India Institute of Medical Sciences (AIIMS) - Nagpur🇮🇳 Nagpur, India