Clinical trial

The Effect of Pharmacotherapy With GLP-1 and GIP/GLP-1 Analogs on Changes in Qualitative and Quantitative Parameters of the Diet as Well as Metabolic and Behavioral Parameters in Patients With Excess Body Weight

Recruiting now · Not applicable · 1 countries · Registry ID NCT07270497

Recruiting nowNot applicableObservational

What this study is about

The aim of this study is to comprehensively assess the early and long-term effects of GLP-1 and GIP/GLP-1 analogue medications on metabolic and behavioral parameters, with particular emphasis on qualitative and quantitative dietary changes in patients undergoing treatment for overweight and obesity. Participation in the study will involve four follow-up visits per year at the Clinic of Diabetology and Internal Medicine, Central Clinical Hospital, University Clinical Clinical Hospital, Medical University of Warsaw: before treatment initiation and after 3, 6, and 12 months. The analysis will focus not only on metabolic effects (weight loss, changes in body composition, and improved biochemical parameters), but also on nutritional and behavioral aspects, including diet, appetite regulation, risk of malnutrition and muscle loss, and the occurrence of adverse events. The study will allow for a multifaceted assessment of the impact of treatment with GLP-1 and GIP/GLP-1 analogues on patients with excess body weight.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 65 Years

SexAll

Healthy volunteersNot accepted

ConditionGLP-1, Nutrition

Full registry criteria

Inclusion Criteria: * Age 18-65 years, * Diagnosed obesity (BMI ≥ 30 kg/m²) or overweight (BMI ≥ 27 kg/m²) with comorbidities associated with excess body weight (including type 2 diabetes, hypertension, dyslipidemia, obstructive sleep apnea, cardiovascular disease), * Eligibility for treatment with GLP-1 or GIP/GLP-1 analogues, * Not taking GLP-1 and GIP/GLP-1 analogue medications for at least one year prior to study enrollment, * Ability to provide informed consent, * Informed consent to participate in the study. Exclusion Criteria: * Age under 18 or over 65 years, * Inability to qualify for treatment with GLP-1 and GIP/GLP-1 analogues, * Pregnancy or breastfeeding, * Diagnosed eating disorders, * Active cancer or gastrointestinal conditions that may affect the absorption or tolerance of treatment (e.g., inflammatory bowel disease, conditions after extensive gastrointestinal resections, conditions after bariatric surgery), * Inability to participate in regular follow-up visits, * Inability to provide informed consent, * Failure to provide informed consent to participate in the study.

Treatments and study arms

The registry does not list a named intervention.

Primary outcomes

change in body weight12 months

percentage change in body weight from baseline to the end of follow-up

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Klinika Diabetologii i Chorób Wewnętrznych Uniwersyteckiego Centrum Klinicznego Warszawskiego Uniwersytetu Medycznego🇵🇱 Warsaw, Warszawa, Poland

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Leszek Czupryniak, professorContact

Email · Call 602245254

Maja Sosnowska, masterContact

Email · Call 696665002