Clinical trial

Supplementation With Sirtuin Activators in Women With Increased Body Weight

Recruiting now · Not applicable · 1 countries · Registry ID NCT07245979

Recruiting nowNot applicableInterventional

What this study is about

The goal of this clinical trial is to learn if the six-month supplementation with sirtuin activators can affect metabolism in 40-to-65-year old women with increased body weight. The main questions it aims to answer are: Does sirtuin activators affect lipid and carbohydrate metabolism? Does sirtuin activators affect oxydative stress, immune functions and cell ageing? Researchers will compare sirtuin activators to a placebo (a look-alike substance that contains no drug) to see if drug sirtuin activators works to improve metabolic status. Participants will: Take sirtuin activators or a placebo every day for 6 months. Visit the university once every 3 months for checkups and tests.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age40 Years to 65 Years

SexFemale

Healthy volunteersAccepted

ConditionObesity & Overweight

Full registry criteria

Inclusion Criteria: * females * age: 40-65 years * overweight or obese: BMI \>25 kg/m2 Exclusion Criteria: * males * BMI \< 25 kg/m2 * sirtuin activators administration for 3 months prior to study * pregnancy or breastfeeding * recent dieting or being on calorie restricted diet * receiving pharmacotherapy to treat obesity, diabetes or hyperlipidemia * post-bariatric surgery * diabetes * cancer * chronic kidney, liver or autoimmune diseases * alcohol addiction

Treatments and study arms

Sirtuin activators

Dietary Supplement

Sirtuin acitivators supplementation for 6 months

Placebo

Dietary Supplement

Placebo supplementation for 6 months

Primary outcomes

Concentrations of blood lipids6 months, two measurements: at month 0 and 6

Total cholesterol, Triacyglycerols, low density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesteroll

Blood glucose concentrations6 months, two measurements: at month 0 and 6

Blood glucose concentration

Ageing biomarkers: transcription level of the p16INK4a gene in peripheral blood mononuclear cells6 months, two measurements: at month 0 and 6

transcription level of the p16INK4a gene in peripheral blood mononuclear cells

Ageing biomarkers: telomere lenght6 months, two measurements: at month 0 and 6

telomere lenght measured in DNA isolated from whole blood

Ageing biomarkers: SA beta galactosidase activity6 months, two measurements: at month 0 and 6

SA beta galactosidase activity

Oxidative stress6 months, two measurements: at month 0 and 6

activities of oxidative stress enzymes in blood

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Poznan University of Life Sciences🇵🇱 Poznan, Poland

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Agata Chmurzynska, ProfessorContact

Email · Call +486184661

Emilia ZawiejaSub Investigator

Monika Mlodzik-CzyzewskaSub Investigator