Clinical trial

Body Composition and Exercise to Prevent Muscle Loss With GLP1 Agonist Treatment

Recruiting now · Not applicable · 1 countries · Registry ID NCT07226947

Recruiting nowNot applicableInterventional

What this study is about

The goal of this study is to learn if a smartwatch that measures activity level and body composition, combined with exercise reminders, can safely improve strength and muscle mass in people who recently started or are planning to start treatment with incretin therapy (liraglutide, semaglutide, tirzepatide or retatrutide), also known as glucagon-like peptide 1 receptor agonist (GLP-1 RA) medications.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 99 Years
SexAll
Healthy volunteersNot accepted
ConditionObesity, Body Composition

Full registry criteria

Inclusion Criteria 1. Age ≥ 18 years old at time of signing informed consent 2. Started treatment with incretin therapy (liraglutide, semaglutide, tirzepatide, or retatrutide) within the past 2 months or planning to start this treatment a. Potential participants switching GLP1-RA therapies due to inadequate response to a prior treatment will be eligible for enrollment 3. Able to provide informed consent Exclusion Criteria 1. Current pregnancy (positive urine hCG) or plans to become pregnant in the next 6 months 2. BMI \<25 kg/m2 at the time of screening 3. Unable to participate in a regular physical exercise program 4. Implanted pacemaker 5. Any factors that, in the opinion of the principal investigator, would interfere with the safe completion of the study

Treatments and study arms

Smartwatch activity and body composition monitor

Device

Participants will be provided a smartwatch to monitor their exercise and body composition

General guidance on recommended exercise

Behavioral

Participants will receive general guidance on recommended exercise

Primary outcomes

Lean mass (kg)6 months

Dual-energy X-ray absorptiometry (DXA) body composition measure

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Diabetes Research Center🇺🇸 Boston, Massachusetts, United States
Ben O Brenner, BSContact
Grace Kuropatkin, BSContact
Melissa S Putman, MDPrincipal Investigator