Clinical trial

Metabolic Effects of Short-term Ultra-processed Food Intake (MEST-UPF)

Recruiting now · Not applicable · 1 countries · Registry ID NCT07213245

Recruiting nowNot applicableInterventional

What this study is about

The overall aim of this project is to study the effects of short-term high ultra-processed food intake, compared to nutrient- and energy density matched low ultra-processed food (UPF) intake, on energy intake and appetite. A total of 24 men and women who meet all inclusion criteria and none of the exclusion criteria will be invited to participate. A randomized 2\*2 factorial four-way crossover study will be conducted at the Department of Internal medicine and Clinical Nutrition at the University of Gothenburg, comparing a high-UPF meal to a low-UPF meal also with high and/or low energy density. A supervised breakfast meal will be served, and postprandial blood samples and appetite measures will be collected continuously up to 4 hours after the breakfast meal. Subsequently, an ad libitum lunch meal will be served, and energy intake will be recorded.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 50 Years
SexAll
Healthy volunteersAccepted
ConditionAppetite, Obesity and Obesity-related Medical Conditions

Full registry criteria

Inclusion Criteria: * Body mass index (BMI) 18.5-30 kg/m2 * Fasting glucose \< 6.1 mmol/l * Hb \>110 g/L * Weight stability the last 3 months +/-5% Exclusion Criteria: * Food allergies, intolerances or preferences preventing consumption of any products included in the study. * Unable to sufficiently understand written and spoken Swedish or English to provide written consent and understand information and instructions from the study personal. * Pregnant, lactating or planning a pregnancy during the study period. * Blood donation or participation in a clinical study with blood sampling within 30 days prior to screening visit and throughout the study. * History of gastrointestinal conditions or major gastrointestinal surgery (Inflammatory bowel disease, Crohn's disease, malabsorption, colostomy, bowel resection, gastric bypass surgery etc.). * Type 1 diabetes or type 2 diabetes. * Thyroid disorder. * Current smoking, vaping. * Following any weight reduction program or having followed one during the last 6 months prior to screening. * Not habitually eating breakfast (\<5 times/week). * Restrained eating based on the three-factor eating questionnaire.

Treatments and study arms

Meal high in energy density, high in ultra-processed food

Other

Meal high in energy density, high in ultra-processed food

Meal high in energy density, low in ultra-processed food

Other

Meal high in energy density, low in ultra-processed food

Meal low in energy density, high in ultra-processed food

Other

Meal low in energy density, high in ultra-processed food

Meal low in energy density, low in ultra-processed food

Other

Meal low in energy density, low in ultra-processed food

Primary outcomes

Self-reported appetiteBaseline to 8 hours after test meal

Appetite ratings (hunger, fullness, and desire to eat) will be assessed using separate 100-mm Visual Analogue Scales (VAS), anchored with "not at all" (0 mm) and "extremely" (100 mm). Higher scores indicate greater perceived intensity.

Energy intake4 hours after test meal

Energy intake estimated by nutrient calculation of leftover food at the ad libitum lunch meal

Gastrointestinal hormones - incretinsBaseline to 4 hours after test meal

Difference between groups in incretins GIP and GLP-1 in response to meal

Gastrointestinal hormones - cholecystokininBaseline to 4 hours after test meal

Difference between groups in cholecystokinin in response to meal

Gastrointestinal hormones - peptide YYBaseline to 4 hours after test meal

Difference between groups in peptide YY (PYY) in response to meal

Gastrointestinal hormones - ghrelinBaseline to 4 hours after test meal

Difference between groups in ghrelin in response to meal

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Department of internal medicine and clinical nutrition, University olf Gothenburg🇸🇪 Gothenburg, Sweden
Therese Karlsson, PhDContact