TrialGlobe

Clinical trial

Is There a Relationship Between Uric Acid Level and Liver Fibrosis in Obese Patients

Opening soon · Not applicable · 0 countries · Registry ID NCT07168551

Opening soonNot applicableObservational

What this study is about

1. Identifying the association between hyperuricemia and NAFLD can lead to early detection and prevention of liver fibrosis in adult obese patients. 2. Understanding the relationship between hyperuricemia and NAFLD can inform targeted therapy, such as urate-lowering treatment, to potentially slow disease progression. 3 - To examine the relationship between serum uric acid levels and liver fibrosis severity\*: Assessing the correlation between serum uric acid levels and the severity of liver fibrosis in adult obese patients with NAFLD. 4- To identify potential mechanisms underlying the association\*: Exploring the potential mechanisms by which hyperuricemia may contribute to the development and progression of NAFLD and liver fibrosis in adult obese patients.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 65 Years
SexAll
Healthy volunteersAccepted
ConditionHyperuricemia, NAFLD (Nonalcoholic Fatty Liver Disease), Liver Fibrosis

Full registry criteria

Inclusion Criteria: 1. Age: Adults (typically 18-65 years old) 2 - Body Mass Index (BMI): Obese patients with a BMI ≥ 30 kg/m² 3- Hyperuricemia : Elevated serum uric acid levels (typically \> 7 mg/dL for men and \> 6 mg/dL for women) Exclusion Criteria: * excessive alcohol consumption ( \> 20 gm /day in men and 10 in g /day in women ) 2- use of steatogenic within the past 6 months 3- positive test for hepatitis B surface antigen and hepatitis B core antibody 4- Drug induced liver injury and autoimmune hepatitis 5 - cirrhosis and other causes of liver disease

Treatments and study arms

*Lab Methods:* 1- Serum Uric Acid levels 2-Liver Function Tests 3- Lipid Profile . 4- Haemoglobin A1c level . 5- Serum glucose level .

Diagnostic Test

Lab methods

*Imaging Studies:* 1- Ultrasound 2 - FibroScan

Radiation

Imaging

Instruments:* 1- *Automated Analyzers*: Used for blood tests, such as serum uric acid and liver function tests.

Device

Instrument

Primary outcomes

Prevalence of NAFLD1 year

The proportion of adult obese patients with NAFLD in the study population

Study locations

0 locations were listed when this page was built. The first 40 are shown.

No public site location was included in this record. Check the original registry for updates.