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Clinical trial

Changes in Body Composition of Patients With Obesity Related Tumors and Their Impact on Clinical Outcomes: a Multicenter Prospective Cohort Study

Opening soon · Not applicable · 1 countries · Registry ID NCT07161167

Opening soonNot applicableObservational

What this study is about

Over the past 20 years, China's obesity rates have surged, increasing cancer burden. Obesity links to 13 cancers via metabolic effects of visceral fat and insulin resistance, while sarcopenic obesity (BMI-independent) may worsen outcomes. Traditional BMI lacks precision; advanced methods (e.g., BIA/CT) are needed. Existing studies show inconsistent results, possibly due to heterogeneity. This multicenter prospective cohort study uses imaging to assess body composition changes (fat/muscle) in obesity-related tumors and their impact on survival, recurrence, and quality of life, and explore the underlying mechanism.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to Not listed
SexAll
Healthy volunteersAccepted
ConditionObesity Rekated Cancer, Body Composition Changes, Survival, Mechanism

Full registry criteria

Inclusion Criteria: 1. Age ≥18 years, regardless of gender. 2. Histologically or cytologically confirmed obesity-associated malignant tumors (e.g., breast cancer, colorectal cancer, gastric cancer, lung cancer, or thyroid cancer) with planned treatment after diagnosis (any treatment modality permitted). 3. No prior chemotherapy, radiotherapy, biologic therapy, immunotherapy, or other antitumor treatments for malignancy. Exclusion Criteria: 1. Patients with concurrent non-obesity-related malignancies. 2. History of prior malignancy (except completely cured carcinoma in situ of the cervix, basal cell carcinoma, or squamous cell carcinoma of the skin). 3. Patients with concurrent multiorgan dysfunction syndrome, autoimmune diseases, infectious diseases, neurological disorders, or psychiatric disorders.

Treatments and study arms

The registry does not list a named intervention.

Primary outcomes

Overall survivalFrom date of diagnosis until the date of death from any cause, assessed up to 10 years

The time from the start of follow-up to death (for any reason).

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Peking union medical college hospital🇨🇳 Beijing, Beijing Municipality, China
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