Clinical trial

Fat Around Heart Arteries as a Measure of Inflammation in Patients With Glycometabolic Disease

Active, not recruiting · Not applicable · 1 countries · Registry ID NCT07144670

Active, not recruitingNot applicableObservational

What this study is about

In this study, the objective is to investigate inflammation in the arteries of the heart. A heart CT scan (CCTA) will be used to measure inflammation by assessing the fat tissue surrounding the arteries of the heart. Participants with and without type 2 diabetes who have no heart symptoms have been examined and had a CCTA scan performed. This study aims to answer the following questions: • Is inflammation in the surrounding fat tissue of the heart arteries associated with the following glycometabolic conditions: I) Obesity ii) Prediabetes iii) Type 2 diabetes

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to Not listed

SexMale

Healthy volunteersNot accepted

ConditionObesity &Amp; Overweight, Obesity Type 2 Diabetes Mellitus, Type 2 Diabetes (T2DM), Prediabetes, Inflammation, Adipose Tissue, Adipose Tissue Inflammation

Full registry criteria

Inclusion Criteria: * Above 18 years * Capable of giving written informed consent Exclusion Criteria: * History of CAD * Symtoms of CAD (angina) * Any tachyarrhythmias making CCTA impossible * Estimated glomerular filtration rate (eGFR) under 45 ml/min * Allergy to iodine contrast * Critical illness with life expectancy less than 1 year * Documented heart failure

Treatments and study arms

The registry does not list a named intervention.

Primary outcomes

PCAT Attenuation [Hounsfield Units (HU)] measured by coronary CT angiographyBaseline

PCAT attenuation \[HU\] will be assessed for correlation with the following variables: * BMI \[kg/m²\] \[Continously, and categorized as normal (ref), overweight, obesity class 1, obesity class 2+\]. * Prediabetes, defined as HbA1c: 39-47 mmol/mol \[Categorical: no(ref)/yes\]. * Type 2 diabetes mellitus, defined by WHO criteria \[Categorical: no(ref)/yes\].

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Cardiovascular Research Unit🇩🇰 Svendborg, Denmark

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