Clinical trial

Effect of Glucagon-like Peptide-1 Receptor Agonists (GLP-1 RA) on Gastric Emptying

Invitation only · Not applicable · 1 countries · Registry ID NCT07140289

Invitation onlyNot applicableObservational

What this study is about

This study aims to assess the effect of using Glucagon-like peptide-1 receptor agonists (GLP-1) receptor agonists on gastric emptying on surgical patients and whether specific guidelines need to be established for these patients. GLP-1 receptor agonists are mainly used for the treatment and mitigation of obesity and metabolic syndromes. One of their mechanisms of action is by delaying gastric emptying, hence increasing satiety. However, patients need to abstain from eating for a set amount of time before surgery to reduce the risk of aspiration. Hence patients who use GLP-1 receptor agonists may need more time to abstain eating (nil-per-os). In this study we aim to assess how much time is sufficient before surgery in these specific population of patients.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 90 Years

SexAll

Healthy volunteersAccepted

ConditionGastric Emptying, Glucagon-Like Peptide-1 Receptor Agonists, Intermittent Fasting, Intraoperative Complication Due to Anesthesia, Respiratory Aspiration of Gastric Contents

Full registry criteria

Inclusion Criteria: * Adult patients who are receiving Glucagon-like peptide-1 Receptor Agonist medication and scheduled for any elective surgery or procedure under anesthesia. * The patient has provided informed consent for the study Exclusion Criteria: * Pregnant patients * Patients with abnormal gastric anatomy like previous gastric resection or bypass( gastric band in situ, previous fundoplication, hiatus hernia * Inability to consent * Emergency surgery * Cognitive impairment (due to the mixed reasons of potential misunderstanding of the aim of the study and inability to provide informed consent, potential inability to provide detailed fasting regimen before the surgery, potential for impaired use of GLP-1 agonists before the surgery) * Terminal illness (due to the effect of chronic illness on the physiologic functions of gastrointestinal tract and gastric emptying)

Treatments and study arms

Ultrasound of gastric contents

Diagnostic Test

An ultrasound examination of the abdomen to observe and measure gastric contents

Primary outcomes

Gastric cross-sectional areaPreoperatively on the day of surgery (between admission to preoperative testing and start of surgical procedure).

Ultrasound measurement of the right- lateral cross-sectional area measurement of the gastric antrum measured pre-operatively

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Detroit Medical Center🇺🇸 Detroit, Michigan, United States

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