Clinical trial
tDCS Intervention in Breast Cancer Survivors With and Without Obesity Reporting Cognitive Impairment
Recruiting now · Not applicable · 1 countries · Registry ID NCT07112521
What this study is about
The goal of this intervention is to investigate whether transcranial Direct Current Stimulation (tDCS) can alleviate Cancer-Related Cognitive Impairment (CRCI) in breast cancer survivors, as measured by changes in brain structures and cognitive performance. To assess the efficacy of tDCS, the investigators will compare outcomes between participants receiving active stimulation and those receiving sham stimulation (a placebo condition where participants believe they are receiving stimulation, but are not). Participants will: * Undergo a baseline MRI session * Receive either active or sham tDCS for six weeks * Undergo a follow-up MRI session * Complete cognitive tests and respond to psychosocial questionnaires before, during, and after the tDCS intervention
Basic eligibility
Full registry criteria
Treatments and study arms
active tDCS
The anodal electrode will be placed over the left DLPFC (F3), and the cathodal electrode will be placed over the right supraorbital area (FP2). The current will be gradually ramped up to 2mA over 30 seconds, held constant at 2mA for 29 minutes, and then gradually ramped down to 0mA over the final 30 seconds.
sham tDCS
The anodal electrode will be placed over the left DLPFC (F3), and the cathodal electrode will be placed over the right supraorbital area (FP2). The current will be initially ramped up to 2mA over 30 seconds and immediately ramped back down to 0mA.
Primary outcomes
Performance in the Matching Cards task under active tDCS compared to sham: the mean number of correct trials.
Performance in the dot memory task under active tDCS compared to sham: the mean Euclidean distance score. The mean Euclidean distance score reflects the distance between the original red dot locations and the recalled locations.
Performance in Symbol Search task under active tDCS compared to sham: prompt-level median response latency for correct trials.
Study locations
1 locations were listed when this page was built. The first 40 are shown.