Clinical trial

Gastric Emptying With Metoclopramide in GLP-1 Agonist Patients Undergoing Elective Surgery

Opening soon · Phase 4 · 1 countries · Registry ID NCT07100691

Opening soonPhase 4Interventional

What this study is about

This is a multicentre, investigator-blinded, randomised controlled trial evaluating whether the use of oral metoclopramide before surgery can reduce the amount of residual gastric content in patients who are taking glucagon-like peptide-1 receptor agonists (GLP-1 RAs) for weight loss. These medications are known to slow down gastric emptying, which may increase the risk of pulmonary aspiration during anaesthesia. Patients will be randomly assigned to either receive metoclopramide 24 hours before surgery or continue with standard care. The primary outcome will be the presence or absence of residual gastric content on ultrasound before surgery. Secondary outcomes include nausea, vomiting, constipation, and any adverse effects of the medication.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to Not listed

SexAll

Healthy volunteersNot accepted

ConditionPulmonary Aspiration During Anaesthetic Induction, Gastric Emptying Time, Preoperative Risk Assessment, Obesity (Disorder)

Full registry criteria

Inclusion Criteria: * Patients taking GLP-1 receptor agonists (for weight loss only) * Male and female patients aged 18 years or older * Able to provide written informed consent * ASA grade I-V * Scheduled for elective surgery with an expected overnight hospital stay Exclusion Criteria: * Inability to provide informed consent * Presence of hiatus hernia * History of any gastric surgery * Pregnancy * Inability to lie in the right lateral decubitus position * Patients taking chronic opioids * Poorly controlled diabetes (HbA1c \>69 mmol/mol) * Urgent or emergency surgery, including trauma * Diagnosis of Parkinson's disease * Allergy or intolerance to metoclopramide

Treatments and study arms

Metoclopramide

Drug

Oral metoclopramide 10 mg, administered as three doses the day before surgery and one dose on the morning of surgery (total four doses over 24 hours). Used to enhance gastric emptying in patients taking GLP-1 receptor agonists.

Primary outcomes

Presence of residual gastric content on preoperative gastric ultrasoundOn the day of surgery prior to anaesthesia induction

Residual gastric content (RGC) will be defined as the presence of any of the following on ultrasound prior to induction of anaesthesia: (1) solid content, (2) thick fluid, or (3) clear fluid \>1.5 mL/kg in the gastric antrum. Ultrasound will be performed in the supine and right lateral decubitus positions by a blinded anaesthesiologist and reviewed by a second blinded assessor.

Study locations

2 locations were listed when this page was built. The first 40 are shown.

National Orthopaedic Hospital Cappagh🇮🇪 Dublin, Dublin 5, Ireland

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Aneurin MoorthyContact

Email · Call 0035318140400

Rotunda Hospital🇮🇪 Dublin, Ireland

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Ryan HowleContact

Email · Call 0035318171700