Clinical trial

24-h Energy Expenditure and Anti-obesity Medication

Invitation only · Not applicable · 1 countries · Registry ID NCT07041983

Invitation onlyNot applicableObservational

What this study is about

This study investigates the long-term effects of anti-obesity medications (Semaglutide and Tirzepatide) on energy metabolism (24-hour energy expenditure and substrate oxidation) and body composition via Dual-energy X-ray absorptiometry (DXA)

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 80 Years

SexAll

Healthy volunteersNot accepted

ConditionObesity

Full registry criteria

Inclusion Criteria: * Body mass index (BMI) \>= 30 kg/m² or \>= 27 kg/m² with at least one weight-related comorbidity and stable body weight (±2 kg in prior 3 months) * informed consent, adherence to study protocol, negative pregnancy test and contraception use (if applicable), and absence of cardiovascular events or end-organ damage. Exclusion Criteria: * psychiatric conditions impairing adherence, history of medullary thyroid cancer, pregnancy/lactation * diabetes

Treatments and study arms

anti obesity medication

Drug

Patients with obesity or overweight, with at least one weight-related comorbidity who are expected to start treatment with Semaglutide (Wegovy) or Terzepatide (Mounjaro) at enrolment will be eligible to enrol into the study. Patients will be treated and observed according to normal clinical practice. Participation in this study does not limit the physicians' clinical decision making as to the most appropriate treatment for the patient during the course of the study

Primary outcomes

change in 24h energy expenditure after 6 months of treatmentBaseline and 6 months after treatment initiation

measurement of 24-hour energy expenditure (kilocalories) by using the metabolic chamber (whole room indirect calorimeter) at baseline and after 6 months of treatment

Study locations

1 locations were listed when this page was built. The first 40 are shown.

university hospital of Pisa🇮🇹 Pisa, Italy

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