Clinical trial

Metabotyping of Broccoli Microgreen in Obese Breast Cancer Survivors

Recruiting now · Not applicable · 1 countries · Registry ID NCT07032545

Recruiting nowNot applicableInterventional

What this study is about

Obesity can pose significant challenges to maintaining long-term health in cancer survivors by increasing their risk of cancer coming back. Eating a healthy diet is an important way to help manage weight and improve overall health. Broccoli microgreens (BMG) are young broccoli plants packed with nutrients, and research suggests they may help prevent cancer. Previous studies in mice showed that BMG can improve gut health and metabolism, leading to better health outcomes in obese animals. This study will test whether BMG can be a useful addition to the diet of obese breast cancer (BC) survivors who have a higher risk of their cancer returning. 24 obese BC survivors will be invited to eat one serving (one cup, \~57 gram) of fresh BMG every day for two weeks. This will help understand if people can stick to this diet, how their bodies respond, and whether it affects metabolism and inflammation-two key factors linked to cancer risk. Biological markers such as body fat, glucose and lipids as well as gut bacterial changes will be analyzed to see how BMG affects individual health. This study may help create new diet strategies to improve health, reduce cancer risk, and support long-term recovery in cancer patients who are overweight or obese. In the future, this research could help doctors personalize nutrition plans to better support cancer survivors.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

AgeNot listed to Not listed

SexFemale

Healthy volunteersNot accepted

ConditionObesity and Overweight, Breast Cancer Survivorship

Full registry criteria

Inclusion Criteria: * Female * Had a diagnosis of breast cancer (Stage I-III) * 2 to 60 months post-curative treatment (surgery, chemotherapy, and/or radiation) * BMI \> 30 kg/m² (obese classification) * Willing to avoid cruciferous vegetables during the study * Able to sign an IRB-approved consent form Exclusion Criteria: * Have any contraindications to the proposed nutrition intervention as identified by their medical provider, their designee, or the study team (e.g., GI conditions, medication requirements, pregnancy, breastfeeding, recent history of an eating disorder). * Allergy or intolerance to cruciferous vegetables * Currently taking broccoli extract supplements

Treatments and study arms

Broccoli microgreen (BMG)

Other

All participants will consume one serving size (one cup, \~57 gram) of raw BMG daily for 2-week period of time.

Primary outcomes

Feasibility, as Assessed by the Percentage of Participants Who Enrolled and Completed the Study14 days

Feasibility will be assessed by calculating the percentage of participants who enrolled and completed the study by providing evaluable data at baseline, during the BMG intervention and after 2-weeks treatment.

Compliance, as Assessed by the Percentage of the Participants Who Adhere to the Assigned BMG Intervention14 days

Compliance will be assessed by measuring the percent of the participants who consume the assigned BMG through the recommended cooking method during the 2-weeks of intervention period.

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Breast Evaluation and Treatment Program, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center🇺🇸 Baltimore, Maryland, United States

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Katherine TkaczukContact

Email · Call 410-328-7394