Clinical trial

HIIT in Sedentary Obese Adults: Effects on Metabolic Risk, Body Composition, and FABP4

Recruiting now · Not applicable · 1 countries · Registry ID NCT06973980

Recruiting nowNot applicableInterventional

What this study is about

It is aimed to investigate the responses of Fatty Acid Binding Protein 4 (FABP4), which has been discovered as a novel biomarker of obesity and metabolic diseases, to regular exercise training. The aim of this study is to investigate the effects of high-intensity interval training (HIIT) on cardiometabolic risk factors, body composition, and plasma FABP4 levels in sedentary obese adults.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age20 Years to 35 Years

SexAll

Healthy volunteersAccepted

ConditionHigh-Intensity Interval Training

Full registry criteria

Inclusion Criteria: * Aged between 20 and 35 years, * BMI between 30 and 35 kg/m², * Waist circumference of 90-100 cm for women, 105-110 cm for men, * Sedentary lifestyle (\<600 MET-min/week), * Referred by a physician (with a statement confirming no contraindication to exercise)." Exclusion Criteria: * BMI \> 35, * Pregnancy, * Cardiovascular Diseases: Individuals with serious cardiovascular issues, such as uncontrolled hypertension, heart failure, coronary artery disease, or a heart attack within the last 6 months, which could pose a risk during exercise. * Respiratory Diseases: Individuals with chronic respiratory conditions, such as uncontrolled or severe asthma or COPD, who cannot tolerate exercise due to their condition. * Neurological Disorders: Individuals with neurological issues that limit exercise capacity, such as Parkinson's disease, stroke, or multiple sclerosis. * Musculoskeletal Issues: Individuals with chronic musculoskeletal problems, particularly knee or hip osteoarthritis, that may increase the risk of pain or injury during exercise. * Metabolic or Endocrine Disorders: Individuals with uncontrolled metabolic issues, such as diabetes or thyroid disorders, that could cause blood sugar or hormonal fluctuations during exercise. * Acute Infections or Illness: Individuals with acute infections, fever, or recently undergone surgical procedures. * Any health condition that may prevent participation in exercise."

Treatments and study arms

Exercise

Other

The exercises will be applied only to the intervention group for 12 weeks and will be progressively intensified every 4 weeks.

Primary outcomes

Fatty acid-bling protein 4Baseline, week 6 and week 12

The Human FABP4 (Fatty Acid Binding Protein 4, Adipocyte) ELISA Kit/96T/Feiyuebio will be used to evaluate fatty acid-binding proteins in the biological samples collected from the participants.

Complete Blood CountBaseline, week 6 and week 12

used to evaluate overall health and detect a wide range of disorders, including anemia, infection, and many other diseases.

Hemoglobin A1c (HbA1c)Baseline, week 6 and week 12

used to measure the average blood glucose levels over the past 2 to 3 months; commonly used in the diagnosis and management of diabetes.

Hematocrit (HCT)Baseline, week 6 and week 12

sed to measure the proportion of red blood cells in the blood; helps evaluate conditions such as anemia, dehydration, and other blood disorders.

Low-Density LipoproteinBaseline, week 6 and week 12

used to measure the level of "bad" cholesterol in the blood; high levels are associated with an increased risk of cardiovascular disease.

High-Density LipoproteinBaseline, week 6 and week 12

Used to quantify the concentration of high-density lipoprotein (HDL) cholesterol in the bloodstream; elevated levels of HDL are inversely correlated with the risk of cardiovascular diseases, suggesting a protective effect on heart health.

TriglyceridesBaseline, week 6 and week 12

used to measure the concentration of triglycerides (a type of fat) in the blood; elevated levels are associated with an increased risk of cardiovascular disease, metabolic syndrome, and other health conditions.

Fasting Blood Glucose (FBG)Baseline, week 6 and week 12

used to measure the concentration of glucose in the blood after an overnight fast; elevated levels may indicate impaired glucose metabolism or diabetes mellitus.

Study locations

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Eastern Mediterranean University🌐 Famagusta, Cyprus

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Yaşam Direl, MScContact

Email · Call 0090 392 6303939

Mehtap Malkoç, ProffesorContact

Email · Call 0090 392 6303939