Clinical trial

The Interaction of Body Composition, Sex Hormones and Exercise in Men

Recruiting now · Not applicable · 1 countries · Registry ID NCT06970457

Recruiting nowNot applicableInterventional

What this study is about

The overall objective of this project is to advance understanding of the causes of normal weight obesity (NWO) in men, namely the hormone profile and related potential mediating mechanisms, and the efficacy of different modes of exercise to restore body composition and cardiometabolic health in this population.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 79 Years

SexMale

Healthy volunteersAccepted

ConditionNormal-weight Obesity

Full registry criteria

Inclusion Criteria: * Biological male * BMI 18.5 - 24.9 kg/m2 or \>/= 30 kg/m2 * Body fat \<20% or \>/= 25% * Ability and willingness to engage in an exercise training regimen Exclusion Criteria: * Presence of a chronic health condition, or regular use of associate prescribed medications, that would substantially impact study variables * Excessive alcohol use or use of tobacco products, vape products, or illicit drugs * Presence of an electrical implant, such as a pacemaker

Treatments and study arms

Resistance Exercise Training

Behavioral

12-week progressive and individualized resistance exercise training program

Aerobic Exercise Training

Behavioral

12-week progressive and individualized aerobic exercise training program

Primary outcomes

Fat MassBaseline/enrollment only in control participants; Baseline/enrollment/pre-intervention and post-intervention (12 weeks after baseline testing) in intervention participants

Fat mass, measured in kg and as a percentage of total body mass Measured through dual-energy X ray absorptiometry

Lean massBaseline/enrollment only in control participants; Baseline/enrollment/pre-intervention and post-intervention (12 weeks after baseline testing) in intervention participants

Lean mass, measured in kg and as a percentage of total body mass Measured through dual-energy X ray absorptiometry

TestosteroneBaseline/enrollment only in control participants; Baseline/enrollment/pre-intervention and post-intervention (12 weeks after baseline testing) in intervention participants

Human testosterone, measured in serum via Novus Biologicals Human Testosterone ELISA Kit (Colorimetric). Measured in pg/mL.

Human Growth HormoneBaseline/enrollment only in control participants; Baseline/enrollment/pre-intervention and post-intervention (12 weeks after baseline testing) in intervention participants

Human Growth Hormone (HGH), measured in serum via R\&D Systems™ Human Growth Hormone Quantikine ELISA Kit Measured in pg/mL

EstradiolBaseline/enrollment only in control participants; Baseline/enrollment/pre-intervention and post-intervention (12 weeks after baseline testing) in intervention participants

Human estradiol, measured in serum via Novus Biologicals Human Estradiol ELISA Kit (Colorimetric); measured in pg/mL

SHBGBaseline/enrollment only in control participants; Baseline/enrollment/pre-intervention and post-intervention (12 weeks after baseline testing) in intervention participants

Sex Hormone Binding Globulin (SHBG), measured in serum via R\&D Systems™ Human SHBG Quantikine ELISA Kit; measured in pg/mL

Luteinizing HormoneBaseline/enrollment only in control participants; Baseline/enrollment/pre-intervention and post-intervention (12 weeks after baseline testing) in intervention participants

Luteinizing Hormone (LH), measured in serum via Invitrogen™ Luteinizing Hormone Human ELISA Kit; measured in pg/mL

FSHBaseline/enrollment only in control participants; Baseline/enrollment/pre-intervention and post-intervention (12 weeks after baseline testing) in intervention participants

Follicle Stimulating Hormone (FSH), measured in serum via Invitrogen™ Human FSH ELISA Kit; measured in pg/mL

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Oklahoma State University🇺🇸 Stillwater, Oklahoma, United States

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Sam Emerson, PhDContact

Email · Call 405-744-2303

Bree Baker, PhDContact

Email · Call 405-744-9315

Sam Emerson, Ph.D.Principal Investigator