Clinical trial

Nasopharyngeal Airway Combined With Nasal High-flow Oxygen Therapy During Painless Gastroscopy in Obesity Patients

Recruiting now · Not applicable · 1 countries · Registry ID NCT06966934

Recruiting nowNot applicableInterventional

What this study is about

Gastroscopy is a commonly used, direct, and reliable method for screening and diagnosing digestive tract diseases. However, as an invasive examination, it can cause adverse reactions such as pain, nausea, vomiting, and choking cough in patients. Compared with ordinary gastroscopy, painless gastroscopy offers higher comfort and satisfaction for patients and greater convenience for endoscopists during operation. The most common complication of painless gastroscopy diagnosis and treatment is hypoxia. High-flow nasal cannulala (HFNC) provides a higher oxygen concentration and flow rate than an ordinary nasal catheter. It has the functions of heating and humidifying, which can relieve the pressure on the nasal mucosa cilia, keep the airway unobstructed and moist, and reduce the risk of epistaxis. Due to changes in airway anatomical structures such as fat accumulation in the head and neck and hyperplasia of oropharyngeal soft tissues, obese patients are more prone to hypoxia during gastroscopy under sedation. Therefore, HFNC is often used to reduce the occurrence of hypoxia. The nasopharyngeal airway (NPA) is used to maintain the patency of the upper respiratory tract and is suitable for patients with spontaneous breathing but partial obstruction of the upper respiratory tract. It is worth exploring how effective the combination of HFNC and NPA is in improving hypoxemia in obese patients during sedation.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to Not listed

SexAll

Healthy volunteersNot accepted

ConditionHypoxia, Obesity, Gastrostomy

Full registry criteria

Inclusion Criteria: 1. Patients undergoing painless gastroscopy; 2. Patients with an age greater than 18 years old; 3. American Society of Anesthesiologists (ASA) physical status classification from Grade I to Grade III; 4. Body Mass Index (BMI) greater than 28 kg/m² Exclusion Criteria: 1. Patients with contraindications to endoscopic procedures or those who refuse sedation/anesthesia; 2. Patients allergic to propofol, eggs, soybeans, milk, etc.; 3. Patients with gastrointestinal tract obstruction and gastric emptying disorders; 4. Patients with acute pharyngitis, tonsillitis, and upper respiratory tract infections; 5. Patients in the acute exacerbation stage of respiratory diseases such as asthma, bronchitis, and chronic obstructive pulmonary disease (COPD); 6. Patients with acute arrhythmia and those with severe heart diseases (congenital diseases, valvular diseases); 7. Patients with severe hepatic and renal insufficiency who require alternative treatment; 8. Patients with severe mental disorders who need medications to control their symptoms; 9. Patients with moderate or above anemia, abnormal coagulation function, and hematological diseases; 10. Patients with nasal cavity lesions leading to severe nasal congestion; 11. Pregnant and lactating patients.

Treatments and study arms

NPA

Device

After sedation, the nasopharyngeal airway (NPA) is inserted when the patient's breathing becomes slightly slow but stable and the eyelash reflex disappears.

Primary outcomes

incidence of hypoxia6 mintues after gastroscopy completion

75% ≤ SpO2 \< 90% for \<60 s

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Nanjing First Hospital🇨🇳 Nanjing, China

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Tao Shan, MDContact

Email · Call +8618852095135