Clinical trial

Human Genes and Microbiota in Early Life

Recruiting now · Not applicable · 1 countries · Registry ID NCT06926166

Recruiting nowNot applicableObservational

What this study is about

The long-term goal of the Human Genes and Microbiota in Early Life (HuGME) is to explore the short- and long-term effects of maternal microbiota during pregnancy and the microbiota colonization of their offspring early in life and their interaction with the host on maternal-offspring health consequences in later life in the born in Guangzhou cohort study in China. Identification of the effect of microbiota in early life, as well as environmental factors and microbe-host interaction, will lead to a better understanding of disease pathogenesis and provide a foundation for targeted mechanistic investigation into the consequences of microbial-host crosstalk for long-term health. It also can result in new strategies to predict and prevent diseases in later life.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

AgeNot listed to Not listed

SexAll

Healthy volunteersAccepted

ConditionHost and Microbiome, Pregnancy Outcomes, Pregnancy Complications, Neurodevelopmental Disorders, Immune Development, Childhood Obesity, Type 2 Diabetes

Full registry criteria

Inclusion Criteria: Pregnant women with \< 20 weeks of gestation Pregnant women intended to eventually deliver in Guangzhou Women and Children's medical center Permanent residengts of families intended to remain in Guangzhou with their child for ≥3 years Exclusion Criteria: Refuses to have blood and stool samples stored at Born in Guangzhou cohort study Biobank.

Treatments and study arms

No intervention

Other

No intervention

Primary outcomes

Numbers of participants with Childhood diseases. Including:42 days, 6 months, 1, 3, 6, 8-9, 14, and18 years of age

Obesity，asthma，allergic diseases，Delayed neural development，type 1 diabetes，maturity-onset diabetes of the young（MODY), hypertension

Numbers of participants with maternal diseases. Including:during pregnancy, 42 days, 6 months, 1, 3, 6, 8-9, 14, and18 years after delivery

Obesity，asthma，allergic diseases，type 1 diabetes，type 2 diabetes, hypertension , cardiovascular diseases，and obstetric complications，including gestational diabetes，pregnancy induced hypertension, ect.

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Guangzhou Women and Children's Medical Center, China🇨🇳 Guangzhou, China

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Xiu Qiu, MD,PhDContact

Email · Call 86-020-38367160

Jian-Rong He, MD, PhDContact

Email · Call 86-020-38367160