Clinical trial

Pregnancy Cohort Study: Pregnancy as a Window to Future Health

Recruiting now · Not applicable · 1 countries · Registry ID NCT06925815

Recruiting nowNot applicableObservational

What this study is about

The goal of this observational cohort study is to gain deep insights into how metabolic disorders such as obesity or diabetes during pregnancy affect the metabolic and cardiovascular health of mother and child in the short and long term. It will investigate the following questions: * How do maternal metabolic disorders affect pregnancy outcomes? * How do maternal metabolic disorders affect fetal growth? * How do maternal metabolic disorders affect the newborn's metabolism and body composition? * How do maternal metabolic disorders during pregnancy affect breast milk composition? * How do maternal metabolic disorders during pregnancy affect the metabolic health of the mother after birth? Participants in this study are pregnant women who will be asked to come to the clinics for three visits during their pregnancy, as well as for the delivery of their baby, and one time 2-3 months thereafter. At each visit, researchers will perform physical examinations (such as body composition measurements) and collect biological samples (blood, urine, saliva), clinical information, and lifestyle data. At birth, researchers will collect cord blood and breast milk as well as clinical data of the delivery and the health of the baby. Researchers will measure body fat in newborn babies and at 2-3 months of age.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 50 Years

SexFemale

Healthy volunteersAccepted

ConditionHealthy Pregnant Women, Obese Pregnant Women, Gestational Diabetes

Full registry criteria

Inclusion Criteria: * ongoing pregnancy prior to 14th gestational week, women with child wish; above 18 years of age, giving informed consent Exclusion Criteria: * gestational age \> 14th week of gestation; below 18 years of age; fetal genetic anomalies /malformation

Treatments and study arms

The registry does not list a named intervention.

Primary outcomes

Maternal adiposityFrom enrolment to 8-12 weeks post partum

Measured as fat mass and fat-free mass by air displacement plethysmography (via BODPOD) at 10-14 weeks, 20-24 weeks and 34-37 weeks of gestation and 8-12 weeks post partum.

Maternal fasting blood glucosefrom enrollment to 8-12 weeks postpartum

Fasting blood glucose as measured in mg/mL from NaF blood tubes at 10-14 weeks, 24-24 weeks, 34-37 weeks of gestation and 8-12 postpartum.

Maternal blood pressureFrom enrolment to 8-12 weeks postpartum

Blood pressure will be measured at 10-14 weeks, 24-28 weeks and 34-37 weeks of gestation and 8-12 weeks post partum.

Maternal lipid profiles - triglyceridesFrom enrolment to 8-12 weeks post partum

Analysis of serum lipid profiles: triglycerides at 3 time points during pregnancy (10-14 weeks (wks); 24-28wks; 34-37wks), and 8-12 wks postpartum.

Maternal lipid profiles: phospholipidsFrom enrolment to 8-12 weeks post partum

Analysis of serum lipid profiles: phospholipids at 3 time points during pregnancy (10-14wks; 24-28wks; 34-37wks), and 8-12wks postpartum.

Maternal lipid profiles: free fatty acidsFrom enrolment to 8-12 weeks post partum

Analysis of serum lipid profiles: free fatty acids at 3 time points during pregnancy (10-14wks; 24-28wks; 34-37wks), and 8-12wks postpartum.

Maternal lipid profiles: total cholesterolFrom enrolment to 8-12 weeks post partum

Analysis of serum lipid profiles: total cholesterol at 3 time points during pregnancy (10-14wks; 24-28wks; 34-37wks), and 8-12wks postpartum.

Maternal lipid profiles: HDL cholesterolFrom enrolment to 8-12 weeks post partum

Analysis of serum lipid profiles: HDL cholesterol at 3 time points during pregnancy (10-14wks; 24-28wks; 34-37wks), and 8-12wks postpartum.

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Department of Obstetrics and Gynecology, Medical University of Graz🇦🇹 Graz, Styria, Austria

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Evelyn Jantscher-Krenn, PhDContact

Email · Call +43 316 385 80076