Clinical trial

Transcriptional Changes in Isolated Human Adipocytes During Obesity

Invitation only · Not applicable · 1 countries · Registry ID NCT06907212

Invitation onlyNot applicableObservational

What this study is about

Adipocytes play an important role in our body through their function as metabolic energy stores in the form of fat deposits, which are stored when metabolic energy is in excess and released when energy levels are low. In severe obesity, adipose tissue grows through the production of more adipocytes from stem cells (hyperplasia) and the increase in the size of existing adipocytes (hypertrophy). This ability of adipocytes, to maintain their functionality during tissue expansion, is critical in determining the development of obesity-related comorbidities. However, not all adipocytes are the same as adipocyte function differs greatly depending on the depot in which they are found. To elucidate the mechanisms underlying adipocyte adaptability, it is necessary to obtain a deep systems biology understanding of how signaling in different types of adipocytes regulates metabolism and function. Currently, this research group is conducting a systems biology analysis of adipocyte plasticity in obesity in mouse models, but adipose tissue biopsies from different depots in humans are lacking and needed to investigate the regulation of adipocyte function and plasticity in humans. Such studies of adipocytes are crucial for the understanding how obesity affects adipose tissue function and leads to comorbidities.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to Not listed

SexAll

Healthy volunteersAccepted

ConditionObesity, Abdominal, Adiposity

Full registry criteria

Inclusion Criteria: * Age \> 18 years old * BMI\> 19 kg/m2 * Can receive oral and written information and give appropriate consent Exclusion Criteria: * Active viral hepatitis, HIV positive * Autoimmune diseases (i.e. lupus) * Chronic use of corticosteroids (cortisone) * Unable to give appropriate consent * Contraindications for biopsy: bleeding tendency. * Cancer or other comorbidity with an expected survival time of less than 12 months

Treatments and study arms

The registry does not list a named intervention.

Primary outcomes

Adipocytes specific signalingJune 2024 - Sept 2025

RNA sequencing of isolated adipocytes

Gene regulatory networksJune 2024 - Sept 2025

ATAC sequencing of isolated adipocytes to determine the accessible chromatin regions.

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Bispebjerg hospital🇩🇰 Copenhagen, Denmark

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