Clinical trial
Cortisol and Obesity - A Vicious Cycle? Hypoglycemia After Bariatric Surgery - Association With Cortisol Metabolism?
Recruiting now · Not applicable · 1 countries · Registry ID NCT06896682
Recruiting nowNot applicableObservational
What this study is about
The goal of this observational study is to learn about how bariatric surgery affects the metabolism of cortisol. The main question it aims to answer is whether changes in cortisol contribute to the development of reactive hypoglycemia? 100 individuals who have previously undergone bariatric surgery, are planned to be included.
A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.
Basic eligibility
AgeNot listed to Not listed
SexAll
Healthy volunteersAccepted
ConditionPostbariatric Hypoglycemia
Full registry criteria
Inclusion Criteria: Participants must have undergone one of the following bariatric procedures at least 12 months prior: * Roux-en-Y gastric bypass * Gastric sleeve Exclusion Criteria * Pregnancy and breastfeeding * Nephrotic syndrome (kidney disease with protein loss in urine), liver cirrhosis, or severe malnutrition, as these conditions reduce cortisol-binding globulin (CBG) levels, affecting total cortisol concentration * Use of corticosteroid medications, such as prednisolone * Use of opiod-containing medication * Use of medications containing estrogen, such as hormone therapy for menopause * Known adrenal disease affecting cortisol metabolism, including autonomous cortisol production and Cushing's syndrome * Diabetes that does not require medical treatment * Previously diagnosed reactive hypoglycemia after bariatric surgery requiring medical treatment
Treatments and study arms
The registry does not list a named intervention.
Primary outcomes
Changes in serum cortisol during mixed meal test0, 30, 60, 90, 120, 150, 180 minutes (visit 2)
cortisol at nadir glucose during the mixed meal test - cortisol at the start of the meal test
Study locations
1 locations were listed when this page was built. The first 40 are shown.
Esbjerg Hospital🇩🇰 Esbjerg, Denmark