Clinical trial
Circadian Rhythms in Human Adipose
Recruiting now · Not applicable · 1 countries · Registry ID NCT06891534
Recruiting nowNot applicableInterventional
What this study is about
The goal of this study is to understand the underlying circadian rhythms in subcutaneous adipose tissue of humans with our without continuous feeding and how these are altered in people who have obesity.
A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.
Basic eligibility
Age18 Years to 55 Years
SexAll
Healthy volunteersAccepted
ConditionObesity, Abdominal, Feeding Patterns
Full registry criteria
Inclusion Criteria: * BMI 20-25 kg/m2 or 30-37 kg/m2 * For participants with obesity a waist-to-hip ratio of ≥0.95 in males and ≥0.90 in females. * sedentary * females: non pregnant or breastfeeding * ability to provide written informed consent and follow study instructions Exclusion Criteria: * History of mediations that impact adipocyte/lipid metabolism * smoking * insomnia * sleep apnea * sleep medication use * employment in night or shift work * extreme chronotypes * Allergy to lidocaine
Treatments and study arms
Continuous Feeding
Other
Participants will receive 24-hour continuous feeds through an NG tube
Intermittent feeding
Other
Participants will receive 3 boluses of feeding per day at regular meal times through an NG tube to mimic normal meals.
Primary outcomes
rhythmicity of circadian clock mRNA in adipose tissue24 hour
Genes from RNA-seq analysis will be defined as statistically rhythmic.
Study locations
1 locations were listed when this page was built. The first 40 are shown.
Mayo Clinic🇺🇸 Rochester, Minnesota, United States
Kelli A Lytle, PhDContact