Recruiting nowNot applicableObservational
What this study is about
This study aims to understand how adipose tissue (fat) and the gut microbiota (the bacteria in the gut) may influence brain function and cognition. It has been observed that changes in adipose tissue in animals such as mice and Drosophila (a type of insect) affect memory and other brain functions. Additionally, it is believed that the gut microbiota also plays an important role in cognition. This study will explore how gene expression in adipose tissue, blood metabolites, and the gut microbiota are related to cognitive function, such as memory and thinking, in individuals with and without obesity. The investigation will also assess whether these factors can predict changes in the brain over time and how they influence sleep, physical activity, and blood sugar regulation. Advanced technologies will be used to analyze samples of tissue, blood, and microbiota, with the goal of identifying new mechanisms through which obesity affects the brain. This research may contribute to the development of new diagnostic and therapeutic strategies for cognitive problems in individuals with obesity.
A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.
Basic eligibility
Age20 Years to Not listed
SexAll
Healthy volunteersNot accepted
ConditionObesity
Full registry criteria
Inclusion Criteria: * Men and women \>20 years old. * Scheduled for surgical intervention to extract adipose tissue. * Signed informed consent for study participation. Exclusion Criteria: * Not meeting inclusion criteria. * Non-obesity-related systemic diseases (cancer, severe kidney/liver disease). * Systemic diseases with intrinsic inflammation (rheumatoid arthritis, Crohn's disease, asthma, chronic infections (HIV/tuberculosis)) or any type of infectious disease. * Pregnant/breastfeeding women. * Persons under legal/administrative restrictions. * Those with infection symptoms in the past month. * Use of antibiotics/antifungals/antivirals (previous 3 months). * Chronic steroidal/anti-inflammatory drug use. * Major psychiatric history. * Excessive alcohol intake, acute or chronic (\>40g/day (women), \>80g/day (men)) or drug abuse. * Immunosuppressants treatment. * Participants with severe eating disorders. * Serum liver enzymes (GOT, GPT) above twice the upper limit of normal. Obvious signs or symptoms of liver disease, acute or chronic hepatitis. * History of iron balance disorders (e.g., genetic hemochromatosis, hemosiderosis from any cause, atransferrinemia, paroxysmal nocturnal hemoglobinuria). * Creatinine greater than 1.2 and glomerular filtration rate below 40. * Current treatment for malignant neoplasia, other than basal cell or squamous cell skin cancer. * Heart disease classified as class III or IV, known ischemic cardiovascular disease. * Renal failure, history of kidney transplant, or current dialysis treatment. * Chronic constipation (bowel movement frequency ≥ 7 days) .
Treatments and study arms
The registry does not list a named intervention.
Primary outcomes
Glycemic variability36 monthMean and standard deviation of glucose measures in mg/dL using a CGM 10 days.
The percentage of time in glucose target range (glucose level 100mg/dl-125mg/dl)36 months
The glycaemic risk measured with the low blood glucose index (LBGI)36 monthsLow blood glucose index (LBGI) is a parameter that quantifies the risk of glycaemic.
The glycaemic variability measured with mean amplitude of glycaemic excursions (MAGE)36 monthsmeasured in mg/dl
Minutes light sleep36 monthsMean and standard deviation of minutes' light sleep measures by activity and sleep tracker device.
Minutes deep sleep36 monthsMean and standard deviation of minutes' deep sleep measures by activity and sleep tracker device.
Minutes rapid eye movement (REM)36 monthsMean and standard deviation of minutes REM measures by activity and sleep tracker device.
Study locations
1 locations were listed when this page was built. The first 40 are shown.
Institut d'Investigació Biomèdica de Girona (IDIBGI)🇪🇸 Girona, Girona, Spain 