Clinical trial

Weight Changes After Incretin-mimetics

Opening soon · Not applicable · 0 countries · Registry ID NCT06795360

Opening soonNot applicableInterventional

What this study is about

The goal of this study is to identify people at risk of weight regain after stopping an injectable weight loss drug. The main question the investigators aim to answer is: Can weight regain be predicted by measuring circulating Agouti-related peptide, a small protein coming from the brain?

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 50 Years

SexAll

Healthy volunteersNot accepted

ConditionObesity and Obesity-related Medical Conditions

Full registry criteria

Inclusion Criteria: * adults 18 years or older * men and women * prescribed an incretin-mimetic for weight loss and for whom insurance coverage for this specific drug will lapse * any ethnicity Exclusion Criteria: * weight \> or = 400 lb * type 1 or type 2 diabetes * patients taking steroid medications * anemia * heart disease * advanced kidney disease (CKD stage 4 and 5) * decompensated liver disease * hyperthyroidism * untreated hypothyroidism * active cancer * post solid organ or bone marrow transplant * HIV/AIDS * pregnancy/plan for pregnancy in the next 6 months * breastfeeding * post-menopausal women * current smoker * current recreational drug use * night shift or rotating shift workers

Treatments and study arms

discontinuation of weight loss medication

Other

Participants will be studied right before their injectable weight loss medication runs out, and 3 months later

Primary outcomes

weight change3 months

weight trajectories in the 3 months after treatment discontinuation

fasting and post-prandial circulating AgRP3 months

Circulating AgRP will be measured after an overnight fast and during a 3-hour mixed meal test, at baseline (while still on injectable weight loss drug) and 3 months later. The mixed meal will consist in a nutrtional shake consumed in 5 min.

Study locations

0 locations were listed when this page was built. The first 40 are shown.

No public site location was included in this record. Check the original registry for updates.