Clinical trial

Assessment of Pulmonary Function in Relation to the Anesthetic Used in Patients Undergoing Bariatric Surgery

Recruiting now · Not applicable · 1 countries · Registry ID NCT06759623

Recruiting nowNot applicableInterventional

What this study is about

It is known that more or less pronounced impairment of pulmonary function occurs after anesthesia. It has been demonstrated in the postoperative period in both patients undergoing general and regional anesthesia, in patients after intra-abdominal and superficial procedures, in overweight and normal-weight patients. It has also been shown that when general anesthesia is performed with the inhalation anesthetic sevoflurane, there is a slightly smaller reduction in lung function parameters than when only intravenous anesthetics are used. The purpose of this study is to evaluate lung function before induction and after awakening from general anesthesia depending on the inhalational anesthetic used in obese patients undergoing bariatric surgery

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to Not listed

SexAll

Healthy volunteersNot accepted

ConditionObesity and Obesity-related Medical Conditions

Full registry criteria

Inclusion Criteria: * Obese patients qualified for bariatric surgery. Exclusion Criteria: * Patients who have absolute contraindications to spirometry testing, i.e: * with aneurysms of the aorta or cerebral arteries threatening to rupture, after recent vascular surgery * with increased intracranial pressure, after recent intracranial bleeding or head surgery within the cranial cavity * after acute conditions within 6 months prior to surgery such as stroke, myocardial infarction, unstable angina, pneumothorax * with uncontrolled hypertension * after recent eye surgery or a history of retinal detachment * with hemoptysis of unknown etiology. And patients unable to perform spirometry testing

Treatments and study arms

Different drug type for conduction of general anesthesia

Drug

Patients will be randomly divided into two groups: patients for whom general anesthesia will be performed with sevoflurane and patients for whom general anesthesia will be performed with desflurane.

Primary outcomes

Heart rate (HR)Continuously during whole duration of anesthesia

HR will be measured by ecg in beat per minute

Pulse oximetry (SpO2)Continuously during whole duration of anesthesia

SpO2 will be measured by light spectrometry percutaneous sensor in %

End tidal CO2 (etCO2)Continuously during whole duration of anesthesia

etCO2 will be measured by capnography with infrared radiation sensor in mmHg. Sensor will be attached to breathing circuit.

Minimum alveolar concentration (MAC)Continuously during whole duration of anesthesia

MAC will be measured based on exhaled anesthetic gas concentration in absolute numbers

Bispectral index (BIS)Continuously during whole duration of anesthesia

BIS will be measured with Covidien BIS monitoring system in absolute numbers

Train of for (TOF)Every 2.5 minutes during whole duration of anesthesia

TOF will be measured in absolute numbers

Non invasive blood pressure (NIBP)Every 5 minutes during whole duration of anesthesia

NIBP will be measured with oscillometric method in mmHG

Forced vital capacity (FVC)3 months before the surgery and 10 and 30 minutes after the emergence from general anesthesia

FVC will be measured with spirometry

Study locations

1 locations were listed when this page was built. The first 40 are shown.

University Clinical Center🇵🇱 Gdansk, Poland

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Karolina Obara, MDContact

Email · Call 0048 58 349 32 80