Clinical trial

Hop Compounds on the Immune System in Overweight People

Recruiting now · Not applicable · 1 countries · Registry ID NCT06745102

Recruiting nowNot applicableInterventional

What this study is about

The aim of the present study is to determine the effect of Iso-alpha Acids and Xanthohumol from hops on the immune response in overweight participants.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 75 Years

SexAll

Healthy volunteersNot accepted

ConditionInflammatory Response

Full registry criteria

Inclusion Criteria: * BMI 25 - 29,9 kg/m² as well as one or more of the following incipient metabolic diseases: * pre-diabetes (fasting blood glucose 100-125 mg/dL), * fatty liver (grade 1-3), * high-normal blood pressure to mild hypertension (grade 1, systolic 140-159 mmHg) Exclusion Criteria: * History of diseases that could falsify the study results * inflammatory bowel diseases * malignant diseases of the gastrointestinal tract * food allergies * malabsorption * kidney or liver disease (except simple fatty liver) * symptomatic heart failure * Taking medication to treat these diseases * Consumption of special diets (e.g. vegan, gluten-free) * Pregnancy

Treatments and study arms

Xanthohumol

Dietary Supplement

Participants receive a study drink supplemented with Xanthohumol (0 mg = Placebo or 0.75 mg soluble Xanthohumol)

Iso-alpha Acids

Dietary Supplement

Participants receive a study drink supplemented with Iso-alpha Acids (0 mg = Placebo or 45 mg Iso-alpha Acids)

Xanthohumol + Iso-alpha Acids

Dietary Supplement

Participants receive a study drink supplemented with Xanthohumol and Iso-alpha Acids (0 mg = Placebo or 0.75 mg + 45 mg soluble Xanthohumol + Iso-alpha Acids)

Primary outcomes

Changes in parameters of immune response6 hours

Changes in concentration of interleukin 6 (ng/ml) in cell culture supernatant of stimulated cells

Changes in parameters of immune response6 hours

Changes in concentrations of interleukin 1 beta (ng/ml) in cell culture supernatant of stimulated cells

Changes in parameters of immune response6 hours

Changes in concentration of tumor necrosis factor alpha (ng/ml) in cell culture supernatant of stimulated cells

Study locations

1 locations were listed when this page was built. The first 40 are shown.

University of Vienna🇦🇹 Vienna, Austria

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Ina Bergheim, Prof. Dr.Contact

Email · Call +43-1-4277-54981