Clinical trial

Dexmedetomidine Versus Ketamine as Adjuvants in Bariatric Surgery

Opening soon · Not applicable · 0 countries · Registry ID NCT06738043

Opening soonNot applicableInterventional

What this study is about

This randomized controlled trial aims to compare the analgesic efficacy of dexmedetomidine infusion versus low-dose ketamine infusion as adjuvants in bariatric surgery. The study includes 90 patients undergoing bariatric surgery at Menoufia University Hospital, randomized into three groups: dexmedetomidine, ketamine, and control (placebo). Primary outcomes include total morphine consumption intra- and post-operatively. Secondary outcomes include postoperative pain scores, total analgesic consumption, time to first analgesic request, hemodynamic parameters, and patient satisfaction. This study seeks to explore safer, more effective pain management strategies to minimize opioid use in bariatric surgery patients.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 60 Years

SexAll

Healthy volunteersNot accepted

ConditionObesity, Postoperative Pain, Bariatric Surgery

Full registry criteria

Inclusion Criteria: * Patients aged 18-60 years. * Both sexes. * Body mass index (BMI) \> 35 kg/m², scheduled for bariatric surgery. * American Society of Anesthesiologists (ASA) physical status I-II. Exclusion Criteria: * History of hypersensitivity to dexmedetomidine or ketamine. * History of substance abuse or chronic opioid use. * American Society of Anesthesiologists (ASA) physical status III or IV. * Severe hepatic or renal impairment. * Cardiopulmonary disorders. * Severe diabetes mellitus. * Psychiatric disorders, seizures, uncontrolled hypertension (systolic ≥ 140 mmHg or diastolic ≥ 90 mmHg), or heart block.

Treatments and study arms

Dexmedetomidine infusion

Drug

A bolus dose of dexmedetomidine (0.5 µg/kg ideal body weight) diluted in 0.9% normal saline is infused over 10 minutes before induction of anesthesia, followed by a continuous infusion at 0.5 µg/kg/h until 10 minutes before the end of surgery.

Ketamine infusion

Drug

A bolus dose of ketamine (0.3 mg/kg ideal body weight) diluted in 0.9% normal saline is infused over 10 minutes before induction of anesthesia, followed by a continuous infusion at 0.3 mg/kg/h until 10 minutes before the end of surgery.

Normal Saline Infusion (Placebo)

Drug

A bolus dose of 0.9% normal saline is infused over 10 minutes before induction of anesthesia, followed by a continuous infusion of 0.9% normal saline until 10 minutes before the end of surgery.

Primary outcomes

Postoperative Total Morphine ConsumptionWithin the first 24 hours postoperatively

The total dose of morphine, measured in mg, administered to each participant during the first 24 hours postoperatively for pain control.

Study locations

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No public site location was included in this record. Check the original registry for updates.