Clinical trial

Impact of Bariatric Surgery and Liraglutide on Cognitive-Behavioral Markers of Long-Term Weight Loss in Obesity

Recruiting now · Not applicable · 1 countries · Registry ID NCT06720246

Recruiting nowNot applicableObservational

What this study is about

The present research project aims to study the effects of bariatric surgery and liraglutide administration (in patients already selected for one of these procedures) on two cognitive-behavioral processes partially supported by distinct brain networks: automatic approach tendencies (underpinned by the cue-reactivity network) and behavioral inhibition (underpinned by the cue-regulation network). Additionally, the investigators aim to study how these processes may be modulated by satiety. The secondary objective of the project includes identifying cognitive-behavioral markers that can predict the response to these treatments.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age20 Years to 60 Years

SexAll

Healthy volunteersNot accepted

ConditionObesity and Overweight

Full registry criteria

Inclusion Criteria: * Subjects of any ethnicity, aged between 20 and 60 years. * BMI equal to or greater than 30 kg/m². * No history of neurological or psychiatric disorders, as confirmed through medical history and neuropsychological screening. * Signed informed consent and willingness to comply with all study procedures. * Patients scheduled for surgery, treatment with liraglutide, or a dietary regimen. Exclusion Criteria: * Previous diagnosis of significant neurological conditions (e.g., brain injury or dementia) or major psychiatric disorders. * Current or past psychopharmacological therapy, if prolonged. * BMI lower than 30 kg/m². * Lack of signed informed consent. * Severe medical conditions, including but not limited to: hypertension, significant cardiac disease, or other disorders that may compromise patient safety. * Confirmed pregnancy through self-report and/or breastfeeding.

Treatments and study arms

The registry does not list a named intervention.

Primary outcomes

Reaction times (approach bias)Baseline and after treatment (2-4 months)

Changes in reaction times (approach bias) in response to pictures of high-calorie and low-calorie foods after treatment.

Accuracy (inhibition)Baseline and after treatment (2-4 months)

Changes in accuracy (inhibition) in response to high-calorie and low-calorie food pictures after treatment.

Study locations

1 locations were listed when this page was built. The first 40 are shown.

IRCCS Ospedale Galeazzi-Sant'Ambrogio🇮🇹 Milan, Milan, Italy

Open map