Clinical trial

Palmitic Acid and Human Microvascular Function

Opening soon · Phase 2 · 1 countries · Registry ID NCT06683534

Opening soonPhase 2Interventional

What this study is about

The goal of this study is to learn how a supplement Quercetin can affect microvascular function. Participants will: * give two blood draws of 5 mL each * have a camera placed under the tongue to take pictures of blood vessels * have 2 laser Doppler microdialysis catheters placed on the forearm to monitor blood vessels before and after local drug infusion Researchers will compare blood vessel function of those who take estrogen supplements to those who do not.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 40 Years

SexAll

Healthy volunteersNot accepted

ConditionMicrovascular Dysfunction, Microvasculature, Cardiovascular Diseases, Cardiovascular Diseases (CVD), Microvascular Health, Obesity and Overweight

Full registry criteria

Inclusion Criteria: * Obesity (BMI\>30) * Aged 18-40 years * English Speaking Exclusion Criteria: * BMI\>60 * Resting SBP ≥180 mmHg or DBP ≥ 110mmHg * Pregnancy or breastfeeding. * Prior history of myocardial infarction * Diagnosis of more than 1 risk factor for coronary artery disease (active smoker, diabetes mellitus- type 1 or 2, congestive heart failure, hyperlipidemia, hypertension) * Active mouth sores that affect the buccal mucosa.

Treatments and study arms

Quercetin (dietary supplement)

Dietary Supplement

Quercetin will be provided to take one Quercetin per day for 30 days to look for differences in microvascular function.

Placebo

Drug

Subjects randomized to receive placebo will be administered a standard placebo sugar pill.

Primary outcomes

Change in blood vessel dilation2 hours

Peripheral microvascular dilation in response to acetylcholine, L-NAME, and sodium nitroprusside infusions will be measured using laser Doppler flowmetry with microdialysis.

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Froedtert Hospital🇺🇸 Wauwatosa, Wisconsin, United States

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Julia VogtContact

Email · Call 4149552348

Julie Freed, MD, PhDPrincipal Investigator