Clinical trial

Beta-Cell - Liver Interactions in Situations of Modified Beta-Cell Function

Recruiting now · Not applicable · 1 countries · Registry ID NCT06682481

Recruiting nowNot applicableObservational

What this study is about

The investigators will measure blood levels of 1,5-anhydroglucitol in obese children with or without type 2 diabetes and correlate them with parameters related to functional beta-cell mass and glucose metabolism. The values will be compared to those obtained in healthy volunteers. The aim of the study is to test the validity of 1,5-anhydroglucitol as a novel biomarker of beta-cell mass and function in children with obesity with or without type 2 diabetes.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age12 Years to 16 Years

SexAll

Healthy volunteersNot listed

ConditionObesity, Childhood, Type 2 Diabetes Mellitus in Obese

Full registry criteria

Inclusion Criteria: * Children aged 12 to 16 years * Obesity. Defined as a body-mass index above the 97th percentile. * Ability to give informed consent as documented by signature Exclusion Criteria: * Patients with diabetes mellitus and positive autoantibodies against islets, insulin, islet antigen 2, glutamic acid decarboxylase or Zinc transporter 8. * Patients with known liver disease (other than NAFLD) * Patients treated with an oral antidiabetic drug, glucagon-like peptide-1 analogues or insulin at the time of or less than 2 weeks prior to inclusion. * Patients treated with a drug known to affect liver function

Treatments and study arms

Measurement of biomarker

Other

Measurement of blood levels of 1,5-anhydroglucitol

Primary outcomes

Correlation of 1,5-anhydroglucitol levels in obese children with indirect markers of beta-cell function and mass and with metabolic controlFirst oral glucose tolerance test

Blood levels of 1,5-anhydroglucitol will be correlated with indirect markers of beta-cell function at 2 timepoints

Correlation of 1,5-anhydroglucitol levels in obese children with indirect markers of beta-cell function and mass and with metabolic controlSecond oral glucose tolerance test, 2 years after the first

Blood levels of 1,5-anhydroglucitol will be correlated with indirect markers of beta-cell function at 2 timepoints

Study locations

1 locations were listed when this page was built. The first 40 are shown.

University Hospital of Geneva🇨🇭 Geneva, Canton of Geneva, Switzerland

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Philippe Klee, MD-PhDContact

Email · Call +41 79 55 33 476

Philippe Klee, MD-PhDPrincipal Investigator