Clinical trial

Clinical Classification and Imaging Markers in Patients of Obesity

Invitation only · Not applicable · 1 countries · Registry ID NCT06649071

Invitation onlyNot applicableObservational

What this study is about

This is an observational study to explore the etiology and clinical classification in patients with obesity and to achieve personalized treatment.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age20 Years to 65 Years

SexAll

Healthy volunteersAccepted

ConditionObesity, fMRI, Clinical Classification

Full registry criteria

Inclusion Criteria: * Patients with BMI≥28kg/m2 * Aged 18-65 years of both sexes, right-handed * At least 6 years of education * Patients agreed and signed the informed consent Exclusion Criteria: * Fewer than 6 years of education * Left-handedness * Dementia * Acute metabolic complications such as diabetic ketoacidosis * Hyperglycaemic hyperosmolar state and hypoglycaemic coma within the previous 3 months; history or presence of neurological or psychiatric disorders; * Presence of hypothyroidism; * History of malignancy, or severe kidney or liver dysfunction.

Treatments and study arms

Naturalistic observation

Other

Naturalistic observation

Primary outcomes

Brain imaging features in patients with obesity by fMRIFrom 2024 to 2028

total brain volume, grey matter volume, white matter volume,cerebrospinal fluid volume, and nuclear bulk volume by MRI-derived normalized measures. All patients underwent odor-induced task fMRI on a 3.0T MR scanner with 222 volumes for task fMRI and 230 volumes for resting-state fMRI.

Biomarkers of patients with obesity by blood sampleFrom 2024 to 2028

Diagnostic biomarkers, predictive biomarkers, and prognostic biomarker in patients with obesity by blood sample

Clinical classification of patients with obesityFrom 2024 to 2028

Based on the exploration of the unique brain imaging and biomarkers in patients with obesity, the clinical classification of obese patients was carried out.

Prevention and intervention strategies for obesity based on clinical classificationFrom 2024 to 2028

According to the clinical classification of obesity investigated in our previous study, personalized prevention and treatment strategies are designed to effectively slow down or reverse the obesity disease.

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Department of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University🇨🇳 Nanjing, Jiangsu, China

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