Clinical trial

Exercise Effects on the Neurobiology Underlying Stress-related Eating Behaviors in Veterans

Opening soon · Not applicable · 1 countries · Registry ID NCT06627569

Opening soonNot applicableInterventional

What this study is about

The purpose of this study is to learn more about how common lifestyle interventions, such as exercise, affect how our brains respond to performing thinking tasks and to viewing pictures of foods and various other objects. The investigators are also interested in how changes in hormones that might be different in men and women could affect how lifestyle interventions change these brain responses.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 75 Years

SexAll

Healthy volunteersAccepted

ConditionOverweight/Obesity, Stress

Full registry criteria

Inclusion Criteria: * Veteran * Body mass index (BMI) of 25 or greater * Physically inactive * Able to attend study visits in person in Aurora, CO Exclusion Criteria: * Currently pregnant * History of bariatric surgery * Current eating disorder * Current treatment with appetite-altering medications (e.g., glucagon-like peptide-1 (GLP-1) agonists) * Contraindication to MRI (weight \> 500 pounds (lbs); claustrophobia; metal or electronic devices in the body) * Cardiovascular disease, chronic kidney disease, pulmonary disease, or diabetes * Unable to exercise due to cardiac, pulmonary, neurologic, or orthopedic reasons

Treatments and study arms

Exercise

Behavioral

12 weeks of aerobic exercise, with 4 sessions per week.

Primary outcomes

Percent change in blood oxygen level dependent (BOLD) response to visual food cues as measured by functional magnetic resonance imaging (fMRI)Baseline, 12 weeks

Percent change in blood oxygen level dependent (BOLD) response from baseline to after the 12-week intervention period while viewing visual food cues. The primary contrast of interest is the comparison of high-calorie food images to nonfood object images.

Change in serum cortisol response to counting taskBaseline, 12 weeks

Change from baseline to after the 12-week intervention period in serum cortisol levels (micrograms per deciliter (mcg/dL)) throughout a counting task involving mental math (measured as area under the curve).

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Rocky Mountain Regional VA Medical Center, Aurora, CO🇺🇸 Aurora, Colorado, United States

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Kristina T Legget, PhDContact

Email · Call (720) 724-5809

Kristina T. Legget, PhDPrincipal Investigator