Clinical trial

Nantes Bariatric Surgery Cohort

Recruiting now · Not applicable · 1 countries · Registry ID NCT06625762

Recruiting nowNot applicableInterventional

What this study is about

While current research suggests that inflammation of adipose tissue in obesity is linked to accelerated aging, it has yet to be determined in humans how this could enhance preventative and personalized medicine for obese individuals. The NBC study aims to investigate : 1. Whether bariatric surgery is associated with changes in biological age 2. If bariatric surgery alters adipocyte dysfunction, the microbiota and biological rhythms 3. Whether changes in adipocyte dysfunction, microbiota and biological rhythms are linked to changes in biological age. To achieve this, establishing a biocollection before, during and after bariatric surgery will be crucial in addressing these questions

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 70 Years

SexAll

Healthy volunteersNot accepted

ConditionObesity

Full registry criteria

Inclusion Criteria : Individuals selected for bariatric surgery (starting the BC pathway within the Nantes University Hospital bariatric unit). Inclusion criteria are those of the Bariatric Surgery program. * male or female, adult over 18 years of age * BMI ≥ 35 kg/m2 with complication(s) or ≥ 40 kg/m2 with or without complication (the list of eligible complications is referenced in HAS 2024 recommendations). In the event of a change in access to bariatric surgery, this threshold could be revised without any substantial change to the protocol. * having consented to their participation in the cohort * participant affiliated to or benefiting from a social security scheme Exclusion Criteria : * Persons protected by law (guardianship or trusteeship) or deprived of their freedom, * Pregnant women (contraindication to CB) or nursing mothers.

Treatments and study arms

Nantes bariatric surgery cohort

Other

The participants will be individuals living with obesity undergoing bariatric surgery

Primary outcomes

Observe how biological age evolves between pre-bariatric surgery and 1 year after bariatric surgery1 year

Biological age will be estimated by measuring phenotypic age. The phenotypic age will be determined from the following variable: albumin, creatinine, fasting glucose, CRP, lymphocyte count, red cell size, alkaline phosphates, leukocyte count.

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Nantes University Hospital🇫🇷 Nantes, Loire-Atlantique, France

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David JACOBI, PU-PHContact

Email · Call 33 2 53 48 27 09

David JACOBI, PU-PHPrincipal Investigator