Clinical trial

Assessment of Taurine Concentration in Older Women With/Without Obesity And With/Without Type 2 Diabetes Mellitus

Active, not recruiting · Not applicable · 1 countries · Registry ID NCT06607068

Active, not recruitingNot applicableObservational

What this study is about

Aging is a multifactorial process marked by several epigenetic and molecular changes, such as telomere shortening, DNA exposure to damage, mitochondrial dysfunction, accumulation of senescent cells, and oxidative stress. Such changes lead to the degeneration of cells and molecules, which affects tissues, organs, and systems over time, reducing the human body\'s ability to resist damage and favoring the development of chronic diseases such as Type 2 Diabetes Mellitus (T2DM). Taurine, a semi-essential amino acid, appears to be related to oxidative homeostasis, glucose control, and inflammation. Therefore, knowing the plasma concentrations of this amino acid in different populations is necessary to obtain a better understanding of the role of taurine in the pathophysiology of obesity and T2DM in older population, in addition to generating hypotheses regarding interventions capable of attenuating oxidative stress and inflammation, which are important hallmarks of aging.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age60 Years to 75 Years

SexFemale

Healthy volunteersAccepted

ConditionObesity and Type 2 Diabetes

Full registry criteria

Inclusion Criteria: Have not exercised regularly for at least 3 months; Exclusion Criteria: 1. use of insulin; 2. consumption of multivitamin supplements or antioxidant vitamins; 3. consumption of mineral supplements such as Copper, Zinc and/or Manganese; 4. liver disease; 5. chronic kidney disease; 6. coronary disease; 7. thyroid disorders; 8. infectious diseases; 9. regular consumption of alcoholic beverages; 10. smoking; 11. the Mini Mental State Examination (MMSE) will be applied, which has a total score ranging from 0-30 points. For the elderly women to be included in the study, they must have a score greater than or equal to 13 points

Treatments and study arms

None (Observational study)

Other

None (Observational study)

Primary outcomes

Plasma taurine concentration1 day at baseline

Collected in EDTA tubes, were centrifuged and the plasma taurine concentration was evaluated using HPLC (high performance liquid chromatography).

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Escola de Educação Física e Esporte de Ribeirão Preto🇧🇷 Ribeirão Preto, São Paulo, Brazil

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