Clinical trial

Treatment and Handling Severe Obesity-Related Comorbidities in Adolescents Through Exercise

Opening soon · Not applicable · 0 countries · Registry ID NCT06520800

Opening soonNot applicableInterventional

What this study is about

The main objective of this project is to analyze the effect of a tailor-made, one-to-one, exercise program (aiming to treat and handle obesity-related comorbidities in adolescents with severe obesity at high risk of cardiovascular disease development) on BMI z-score, specific comorbidities, and other health-related indicators. This project will further allow to analyze the long-term impact of the exercise program not only on clinical parameters, but also on the interaction with drug-treatment, health-related behaviors, and quality of life, further contributing to the understanding of the individual characteristics associated with a positive exercise response and frequency. The secondary objective of the THOR-X project is to build an educational toolkit, based on project results and relevant literature, addressed to health and exercise professionals, in order to improve management of adolescents with obesity, in particular those with severe obesity.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age13 Years to 18 Years

SexAll

Healthy volunteersNot accepted

ConditionAdolescent Obesity, Hypertension,Essential, Non-Alcoholic Fatty Liver Disease, Dyslipidemias, Metabolic Disease, Metabolic Syndrome

Full registry criteria

Inclusion Criteria: * adolescents aged 13 to 18 years; * of any gender (including transgender adolescents); * with severe obesity (≥3.0 BMI z-score) \[24\]; * with any obesity-related comorbidity (e.g., hypertension, IR or DMT2, dyslipidemia, eating disorders, depression/anxiety); * at least 6 months of follow-up at the Pediatric Obesity Clinic (HSM, CHULN) at the time of recruitment; * living in Lisbon area; * informed consent/assent signature. Exclusion Criteria: * major or unstable clinical conditions (other than obesity or its related comorbidities); * inability to perform regular PA; * pregnancy; * mental disorders; * smoking habits; * being involved in another weight loss program.

Treatments and study arms

Treatment and handling obesity-related comorbidities in adolescents through exercise

Behavioral

Tailor-made, one-to-one, physical exercise program

Primary outcomes

Body Mass Index (BMI) z-score6 (end of intervention) and 12 months (end of follow-up)

Calculated according to World Health Organization (WHO) data, using the WHO AnthroPlus calculator (version 1.0.4)

Study locations

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No public site location was included in this record. Check the original registry for updates.