Clinical trial

HIBOC = Hepatic Imaging Biomarkers in Obese Children

Invitation only · Not applicable · 1 countries · Registry ID NCT06463223

Invitation onlyNot applicableObservational

What this study is about

The goal of this prospective, diagnostic observational study is to learn about how imaging based markers for components of liver disease appear in children with obesity. It aims to determine whether the imaging markers (ultrasound and MRI) for liver disease can be tools to improve diagnostics for liver affection in children with obesity and to ascertain how the markers are related to multiple clinical measures, for example BMI and serology measure, and treatment effects over time.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age9 Years to 14 Years

SexAll

Healthy volunteersNot accepted

ConditionElastography, Shear Wave Elastography, Shear Wave Dispersion, Attenuation Imaging, Child Obesity, Metabolic Disease, Metabolic and Genetic Disorder Affecting the Liver, Fibrosis, Liver, Diagnosis, Inflammation; Liver, Steatosis

Full registry criteria

Inclusion Criteria: * Age 9 to 14 years * New referral/first visit or follow-up annual visit at each healthcare center (Child and adolescent oriented centers) included * BMI 30 or more * Obesity \>1 year at inclusion Exclusion Criteria: * Difficulty understanding written/oral information * Comorbidities that can affect the liver (e.g., medications or diseases with known liver impact) * Claustrophobia (applies to the MRI cohort) * Implants or other factors that prevent MRI (applies to the MRI cohort)

Treatments and study arms

The registry does not list a named intervention.

Primary outcomes

Attenuation imagingbaseline, 1 year, 2 years and 3 years follow up

an ultrasound based measure of steatosis in the liver

Shear wave dispersionbaseline, 1 year, 2 years and 3 years follow up

an ultrasound based estimation of increased liver viscosity, seen in for example inflammation

shear wave dispersionbaseline, 1 year, 2 years and 3 years follow up

an ultrasound based measure of liver stiffness as a reflection of liver fibrosis

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Department of Radiology, Queen Silvias Children´s Hospital, Institution of Clinical Sciences🇸🇪 Gothenburg, Västra Götaland County, Sweden

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