Clinical trial

Craving Network Neurofeedback

Recruiting now · Not applicable · 1 countries · Registry ID NCT06426693

Recruiting nowNot applicableInterventional

What this study is about

This project tests whether individuals with overweight or obesity and high craving can learn to change their brain response to food cues using neurofeedback, to impact their craving and eating behavior.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 60 Years

SexAll

Healthy volunteersAccepted

ConditionOverweight or Obesity

Full registry criteria

Inclusion Criteria: * Ages 18 to 60 years * Body mass index \>25 kg/m2 * \>2.37 Food Craving Inventory score Exclusion Criteria: * Current or past 6 months use of anti-obesity medications * Weight-reduced state defined as \>10% weight reduction in the past 6 months. * Nicotine use * Current diagnosis of neurological or psychiatric disorder * Obesity-related diseases such as type-2 diabetes * Contraindications to MRI * Baseline scanning with motion \>0.15mm frame to frame displacement.

Treatments and study arms

Experimental feedback

Device

Participants provided with feedback of target brain activation patterns (e.g., thermometer) and will be instructed to try to change the feedback (e.g., decrease the thermometer).

Control feedback

Device

Participants provided with control (sham, yoked to another participant) feedback (e.g., thermometer) and will be instructed to try to change the feedback (e.g., decrease the thermometer).

Primary outcomes

Change in craving network strength during transfer runsWeek 1 and 3

Craving network strength will be measured during transfer (i.e., no feedback) runs and compared across scan sessions.

Change in Food Craving Inventory Mean ScoreWeek 1, Week 7

Food Craving Inventory has 28 items rated 1-5 and overall mean is calculated, range 1-5 with higher score indicating higher craving. FCI will be compared between baseline and 1 month follow-up.

Change in Automated Self-Administered 24-hour (ASA24®) Dietary Assessment Tool Healthy Eating Index (HEI).Week 1, Week 7

ASA-24 HEI is scored 0-100 with 100 indicating healthier diet and composite scores examined to interpret the overall score. HEI will be compared between baseline and 1 month follow-up.

Change in craving network strength during resting state runsWeek 1 and 3

Craving network strength will be measured during resting state runs and compared across scan sessions.

Change in Food Rating Task healthiness, tastiness, and choice scoresWeek 1, Week 7

Food Rating Task outcomes include healthiness, tastiness, and choice. Healthiness and tastiness mean score is taken, range 1-5, with 5 indicating higher healthiness or tastiness. Choice is counted from 0-48 items choosing the food item over the neutral reference food item, with higher values indicating more frequent choice. Food Ratings will be compared between baseline and 1 month follow-up.

Change in Food Snack Task caloric intakeWeek 1 and 3

Food Snack Task will be used to measure caloric intake (out of a maximum value to calories offered) and compared across scan sessions.

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Yale MRRC Anlyan Center🇺🇸 New Haven, Connecticut, United States

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