Clinical trial

Inflammatory Resolution in Cardiometabolic Health and Disease

Recruiting now · Not applicable · 1 countries · Registry ID NCT06390189

Recruiting nowNot applicableObservational

What this study is about

The specific aim of this study is to determine molecular pathways that differentiate metabolically healthy vs unhealthy human phenotypes, and to investigate the therapeutic potential of pro-resolving lipids. Investigators will recruit volunteers that are metabolically healthy or unhealthy that fall within three BMI ranges: lean (18.-24.9 kg/m2), overweight (25.0-29.9 kg/m2) and obese (\>30.0 kg/m2). Investigators hypothesize that metabolically healthy individuals have a superior endogenous capacity to regulate an inflammatory/resolving response.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 75 Years
SexAll
Healthy volunteersAccepted
ConditionInflammation, Obesity, Cardiovascular Diseases

Full registry criteria

Inclusion Criteria: * Informed signed consent has been obtained from the volunteer. * The volunteer has a BMI greater than 18.5 kg/m2 * Men and women over the age of 18 are included. Exclusion Criteria: * The study staff contacting a potential participant perceives that the individual has difficulty understanding the information. * An MD determines that the individual is on too many medications to participate. * The individual takes a medication that is approved by the MD, but he/she is not willing or not able to wait with any potential morning medication until after their fasted blood-draw. * The individual states that they have increased bleeding tendency or are using anti-coagulant (blood thinning) medication. * The individual has some form of chronic inflammation. * The individual regularly uses medication that affects inflammatory resolution (e.g., low-dose aspirin). * The individual uses immunosuppressive drugs (e.g., methotrexate). * The individual regularly consumes fish oils (omega 3). * The individual has significant gastrointestinal problems. * The individual smokes or uses chewing tobacco. * The individual has been drinking alcohol two days before the study visit. * The individual has tattoos or body piercings on the forearms and / or the stomach that can affect the examination. * The individual does not follow instructions given in the research study.

Treatments and study arms

The registry does not list a named intervention.

Primary outcomes

Inflammation and resolution status measurements in different metabolic phenotypesSeptember 2028

Quantifiable inflammatory resolution by measurement of IL-6 cytokine levels in the acute vs the resolving phase of blister formation.

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Steno Diabetes Center Aarhus, Aarhus University Hospital🇩🇰 Aarhus, Denmark
Emma Börgeson, PhDContact