Clinical trial

Using Tissue-based Spatial Data to Understand How Obesity-related Tumor Metabolites Fuel Prostate Cancer Progression

Recruiting now · Not applicable · 1 countries · Registry ID NCT06292897

Recruiting nowNot applicableObservational

What this study is about

Evaluate the protein expression of lactate dehydrogenase enzyme (LDHA) and MCT-1/-4 transporters, involved in lactate synthesis and transport, in prostate carcinoma tissues from severely overweight/obese (BMI \> 27.5) and non-severely overweight/normoweight (BMI \< 27.5) patients affected by prostate carcinoma. ii. Characterize the immune infiltrate in the prostate carcinoma of the aforementioned patients. iii. Assess the association between intra-tumoral lactate accumulation (using LDHA and MCT-4 protein expression levels as readouts) and alterations in the tumor immune microenvironment and/or deregulation of relevant oncogenic pathways.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to Not listed

SexMale

Healthy volunteersNot accepted

ConditionProstate Cancer, Prostate Adenocarcinoma, Prostate Neoplasm, Prostatic Neoplasm, Obesity

Full registry criteria

Inclusion Criteria: * affected by prostate cancer Exclusion Criteria: \-

Treatments and study arms

observational study

Other

observational study

Primary outcomes

Assess the protein expression of LDHA enzyme and MCT-1/-4 transporters in prostate carcinoma4 years

Study locations

1 locations were listed when this page was built. The first 40 are shown.

IRCCS Cà Granda Ospedale Maggiore Policlinico Milano🇮🇹 Milan, Italy

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giancarlo albo, MDContact