Clinical trial

Early Genetic Identification of Obesity

Active, not recruiting · Not applicable · 1 countries · Registry ID NCT06239064

Active, not recruitingNot applicableObservational

What this study is about

TITLE: Whole genetic approach in Early Genetic Identification of Obesity (WEGIO) DESIGN: Multicenter epidemiological study STUDY POPULATION: Participants at risk for a syndromic or a monogenic genetic obesity, incl. participants clinically diagnosed with Bardet-Biedl-Syndrome (BBS) NUMBER OF PARTICIPANTS: 1000 for initial genetic sequencing and app. 40 for the follow-up documentation COORDINATING INVESTIGATOR: Prof. Dr. Arndt Rolfs

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age2 Years to Not listed

SexAll

Healthy volunteersNot listed

ConditionObesity, Childhood, Hyperphagia, Retinopathy, Syndactyly, Polydactyly, Cognitive Impairment, Bardet-Biedl Syndrome, POMC Deficiency

Full registry criteria

Inclusion criteria: * Informed consent is obtained from the participant/parent/legal guardian * The participant is 2 years of age or older For a participant between 2 and 18 years of age: * The participant has and had a body weight more than 97th percentile before the age of 6 * The participant has one or more of the following symptoms: rod/cone dystrophy, renal abnormalities, ataxia, syndactyly, polydactyly, brachydactyly, hyperphagia, cognitive impairment, speech delay, hypogonadism For a participant who is 18 years of age or older: * The participant has BMI ≥ 30 kg/m2 * The participant had a body weight more than 97th percentile before the age of 6 years * The participant has rod/cone dystrophy * The participant is 2 or more years of age, is clinically diagnosed with Bardet-Biedl-Syndrome (BBS) or is a sibling of an individual diagnosed with BBS via the WEGIO study Exclusion criteria: \- Not fulfilling the inclusion criteria

Treatments and study arms

Genetic testing via blood collection

Diagnostic Test

blood collection

Primary outcomes

BBS prevalence2 years

To investigate the prevalence of BBS in patients suspected to a genetic obesity

Study locations

37 locations were listed when this page was built. The first 40 are shown.

Universitätsklinikum Aachen (RWTH)🇩🇪 Aachen, Germany