Clinical trial
ADAPT Study: Assessing Diet, Appetite and Physiology Throughout Weight Loss Study)
Recruiting now · Not applicable · 1 countries · Registry ID NCT06174389
What this study is about
Behavioral weight loss programs for obesity can result in weight loss and health benefits. However, behavioral weight loss often stops despite efforts to continue losing weight, this can be called an involuntarily weight loss plateau. This study investigates changes in metabolism and/or the brain that contribute to the occurrence of an involuntary weight loss plateau.
Basic eligibility
Full registry criteria
Treatments and study arms
Behavioral Weight Loss Program
Behavioral Weight Loss Program is a modified version of the Diabetes Prevention Program.
Primary outcomes
Mitochondrial maximal respiratory capacity will be measured in fasting samples from peripheral blood mononuclear cells.
fMRI BOLD signal to visual food cues within a priori brain regions of interest pre and post consuming a standardized meal. Meal-induced change will be calculated by post-pre meal BOLD signal.
binary outcome (Y/N) and time from baseline