Clinical trial

Effects of Adjunct Antimicrobial Photodynamic Therapy in Periodontal Treatment of Patients With Obesity

Recruiting now · Not applicable · 1 countries · Registry ID NCT06073704

Recruiting nowNot applicableInterventional

What this study is about

The goal of this clinical trial is to compare the effects of adjuvant antimicrobial photodynamic therapy (aPDT) as an adjuvant of scaling and root planing with scaling and root planing alone for periodontal treatment in patients with periodontal disease and obesity. The main question it aims to answer are: Does adjuvant aPDT improves periodontal health? Are there differences in the proteomic profile of gingival fluid after both treatments? Participants will receive scaling and root planing complemented or not by aPDT. Results will be collected after 1, 3, and 6 months. Researchers will compare adjuvant aPDT treatment to regular treatment to see if it promotes reduction in inflammation and improvement in periodontal health.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 70 Years

SexAll

Healthy volunteersNot accepted

ConditionPeriodontitis, Obesity

Full registry criteria

Inclusion Criteria: * Obesity (grade II and III classified according to Body Mass Index) * Periodontitis stage II to IV * Presence of at least 20 teeth excluding 3rd molars. Exclusion Criteria: * Smokers * Alcohol or drugs consumption * Kidney disorders * Pregnancy or lactation * Use of antibiotics at the last 30 days * Use of drugs that alter periodontal structures as phenytoin or ciclosporin * Periodontal treatment at the last 6 months

Treatments and study arms

antimicrobial photodynamic therapy (aPDT)

Procedure

Scaling and root planing followed by antimicrobial photodynamic therapy

Control

Procedure

Treatment of scaling and root planing

Primary outcomes

Probing depthBaseline, 1, 3 and 6 months

Changes in probing depth measured from the gingival margin to the bottom of periodontal sulcus or periodontal pocket by a periodontal probe in millimeters.

Clinical attachment levelBaseline, 1, 3 and 6 months

Changes in clinical attachment level measured from the cemento-enamel junction to the bottom of periodontal sulcus or periodontal pocket by a periodontal probe in millimeters.

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Bauru School of Dentistry🇧🇷 Bauru, São Paulo, Brazil

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Carla Damante, PhDContact

Email · Call +55 14 32266064

Andreia Pavani, PhDContact

Email · Call +55 14 32358366

Carla Damante, PhDPrincipal Investigator