Clinical trial

Impact of Yo-Yo Sleep on Cardiometabolic Health

Recruiting now · Not applicable · 1 countries · Registry ID NCT05880758

Recruiting nowNot applicableInterventional

What this study is about

The goal of this clinical trial is to test the impact of repeated intermittent short sleep, with short sleep maintained 5 days per week followed by 2 days of prolonged sleep, compared to daily adequate sleep, on energy balance and cardiometabolic risk. A secondary goal of this research is to determine if maintaining a constant midpoint of sleep while undergoing intermittent short sleep, leads to better outcomes than intermittent short sleep with a 2-hour delay in sleep midpoint. The aims of this research will be tested in the context of a 3-group, parallel-arm, outpatient intervention of 4 weeks in duration, in young-to-middle-aged adults (aged 18-49 years).

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 49 Years

SexAll

Healthy volunteersAccepted

ConditionCardiometabolic Syndrome, Obesity

Full registry criteria

Inclusion Criteria: * Aged 18 to 49 years * BMI 20-29.9 kg/m2 * Habitually sleeping 7-9 hours/night without sleep aids or naps Exclusion Criteria: * Sleep disorders * Psychiatric disorders (including eating disorders) and seasonal affective disorder * Pregnancy (current/prior year) * Breastfeeding * Smokers (Any cigarette smoking or ex-smokers \<3years) * Diabetes * Elevated blood pressure, taking beta-blockers * Individuals taking anti-coagulants or anti-platelets * Recent weight change or participation in a weight loss program or have ever had bariatric surgery or other weight loss or gastrointestinal procedure. * Travel across time zones; shift work (non-traditional hours)

Treatments and study arms

Intermittent Short Sleep (ISS)

Behavioral

Restricted sleep duration of \<5.5 h/night for 5 nights (SR) followed by 2 nights of 9.5 hours of time in bed (TIB) (recover sleep) each week.

Social Jetlag (SJL)

Behavioral

2-hour delayed sleep timing.

Sustained Adequate Sleep (SAS)

Behavioral

Goal of ≥7 hours of sleep/night with 8 hours of time in bed (TIB).

Primary outcomes

Fasting Plasma GlucoseUp to 4 weeks

Insulin resistance will be assessed by measuring fasting plasma glucose levels.

Insulin LevelUp to 4 weeks

Insulin resistance will be assessed by measuring insulin levels.

Morning Systolic and Diastolic Blood PressureUp to 4 weeks

Ambulatory blood pressure will be measured.

Evening Systolic and Diastolic Blood PressureUp to 4 weeks

Ambulatory blood pressure will be measured.

Fat massUp to 4 weeks

Body composition will be measured using Dual-energy X-ray absorptiometry (DXA) to determine fat mass.

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Columbia University Irving Medical Center🇺🇸 New York, New York, United States

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Marie-Pierre St-Onge, PhDContact

Email · Call 212-305-9549

Marie-Pierre St-Onge, PhDPrincipal Investigator

Sanja Jelic, MDSub Investigator