Clinical trial

HIIT Effects on Cardiometabolic Health

Recruiting now · Not applicable · 1 countries · Registry ID NCT05838950

Recruiting nowNot applicableInterventional

What this study is about

The primary aim of this randomized clinical trial is to compare the effects of three different HIIT protocols and a control group on cardiometabolic health in young adults with obesity. Participants will be randomly assigned to one of the following three groups, with each having varying work-to-rest ratios: 1) HIIT-A, 2) HIIT-B, 3) HIIT-C, and 4) control group. HIIT-A, HIIT-B, and HIIT-C groups will participate in six sessions of a running based HIIT program over a 2-week training period. Pre-clinical markers of cardiovascular disease, blood lipids and fasting glucose will be measured at the following three time points: baseline, post-intervention, and 2 weeks after the training cessation (i.e., measure for detraining effect). All measurements will be performed three days before the training program and three days after the intervention to avoid the effect of the last training session. Afterwards, the detraining test will be measured 2 weeks post intervention.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 25 Years

SexAll

Healthy volunteersNot accepted

ConditionObesity, Cardiovascular Diseases, Metabolic Disease, High-intensity Interval Training

Full registry criteria

Inclusion Criteria: * Young adults with obesity (Age 18 to 25 years old, BMI ≥ 30 kg/m2). Exclusion Criteria: * Syndromic obesity; 1) Any clinical symptoms including cognitive delay, 2) abnormalities in body structure(s), 3) organ-specific abnormalities (kidney, liver failure, excessive eating, and/or other signs of hypothalamic dysfunction such as fatigue, weakness and/or lack of interest in activities. * Taking weight loss medication(s) * Currently enrolled (or within previous 6 months) in a weight loss program; * An underlying disease/medications (steroids, second generation psychotropic agents, hormonal contraception, statins, antihypertensive and antidiabetic medications) that could influence carbohydrate or lipid metabolism. * Presence of cardiac pacemaker. * Current or anticipated participation in another research that would interfere with any of the outcomes. * Current or anticipated pregnancy.

Treatments and study arms

high-intensity interval training intervention

Other

Intervention groups include 3 arms with 3 different HIIT protocols to identify optimal exercise regimen for improving cardiometabolic health in young adults with obesity.

Primary outcomes

HeightBaseline

Height (cm)

WeightBaseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)

Weight (kg); Change from Baseline weight at 2 week and 4 week

Body mass indexBaseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)

Body mass index (kg/m2); Change from Baseline BMI at 2 week and 4 week

Percentage body fatBaseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)

Percentage body fat (kg); Change from Baseline percentage body fat at 2 week and 4 week

Fat massBaseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)

Fat mass (kg); Change from Baseline fat mass at 2 week and 4 week

Lean massBaseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)

Lean mass (kg); Change from Baseline lean mass at 2 week and 4 week

Systolic blood pressureBaseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)

Systolic blood pressure (SBP, mmHg); Change from Baseline SBP at 2 week and 4 week

Diastolic blood pressureBaseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)

Diastolic blood pressure (DBP, mmHg); Change from Baseline DBP at 2 week and 4 week

Study locations

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Women's Building🇺🇸 Syracuse, New York, United States

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Departments of Exercise ScienceContact

Call 315-443-2115