Clinical trial

Maternal Characteristics Associated With Child Growth and Adiposity

Recruiting now · Not applicable · 1 countries · Registry ID NCT05798676

Recruiting nowNot applicableObservational

What this study is about

The goal of this observational study is to investigate the concentrations of leptin, insulin, liver expressed antimicrobial peptide 2 (LEAP2), and cortisol in plasma and breast milk and their relationship with eating behavior, growth, adiposity and with the levels of these hormones in infants, comparing mothers with normal weight and with pre-pregnancy overweight/obesity. The main question\[s\] it aims to answer are: * Are maternal hormones associated with child growth and adiposity * Are maternal hormone receptors associated with child growth and adiposity * Are infant hormones and their receptors associated with child growth and adiposity * Are maternal and infant hormones and their receptors associated with child eating behavior Participants will provide milk and blood samples. Researchers will compare mothers with normal weight and with pre-pregnancy overweight/obesity to see if there are differences in child growth and adiposity .

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 40 Years
SexFemale
Healthy volunteersAccepted
ConditionObesity, Obesity, Infant

Full registry criteria

Inclusion Criteria: * Lactating women with pre-pregnancy normal weight and overweight or obesity as described by the World Health Organization. Exclusion Criteria: * Diabetes (Type I or II or gestational) * Multiple pregnancy * Hypertensive disorders during pregnancy * Delivery of pre-term infant (\<37 weeks).

Treatments and study arms

overweight/obesity

Other

the consequences of maternal pregestational overweight/obesity on infant´s growth and adiposity will be studied

Primary outcomes

infant weightfrom birth to 2 years old

weight in kilograms

infant heightfrom birth to 2 years old

height in centimeters

infant body mass index (BMI)from birth to 2 years old

weight and height will be combined to report BMI in kg/m\^2

infant upper arm circumferencefrom birth to 2 years old

upper arm circumference in centimeters

infant skinfold thicknessfrom birth to 2 years old

skinfold thickness in centimeters

infant blood leptin concentrationsix months old

blood leptin concentration (ng/ml)

infant blood cortisol concentrationsix months old

blood cortisol concentration (ug%)

infant saliva cortisol concentrationsix months old

saliva cortisol (ug%)

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Instituto de Desarrollo e Investigaciones Pediátricas Prof. Dr. Fernando E. Viteri🇦🇷 La Plata, Buenos Aires, Argentina
Maria F Andreoli, PhDContact
Ana Kruger, BsCContact