Clinical trial

Child Health, Nutrition and Microbiome Development

Active, not recruiting · Not applicable · 1 countries · Registry ID NCT05793294

Active, not recruitingNot applicableObservational

What this study is about

Childhood malnutrition is a global public health issue with devastating consequences on the health, well-being, and psychosocial development of children. Emerging evidence suggests that malnourished children have immature gut microbiota compared to age-matched healthy controls and it does not repair even after nutritional interventions. The present study aims to characterize how the gut microbiome develops during the first two years of life in children residing in malnutrition endemic areas of Khyber Pakhtunkhwa, the region with the highest prevalence of childhood malnutrition in Pakistan and the region.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age1 Day to 28 Days

SexAll

Healthy volunteersAccepted

ConditionMalnutrition, Stunting, Wasting, Underweight, Overweight and Obesity

Full registry criteria

Inclusion Criteria: * Healthy infants aged 0 - 28 days * Born to parents residing in rural and remote areas of District Swat * Living in separate households * Parents/caregivers have no plans to move out of the stud site for at least one year after enrollment in the study. Exclusion Criteria: * Child born to underage (\<18 years old) mother. * Infants born with severe acute or chronic medication conditions that require hospitalization or prolonged use of medication or both or the infant is diagnosed with enteropathies. * Whose parents refused to provide informed consent to participate in the study. * Weight of the child is \<1500 gm.

Treatments and study arms

The registry does not list a named intervention.

Primary outcomes

Gut microbiome profile2 years

Next generation sequencing to asses changes in gut microbiome diversity and functional potential at 0, 3, 6, 9, 12, 18 and 24 months of age. These data will then be categorised on the basis of nutritional status (Healthy, Stunting, Wasting), dietary patterns and health status.

Study locations

2 locations were listed when this page was built. The first 40 are shown.

Khyber Medical University🌐 Peshawar, Khyber Pakhtunkhwa, Pakistan

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Tehsil Matta🌐 Swāt, Khyber Pakhtunkhwa, Pakistan

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