Clinical trial

Food Genetics Behavior Study

Recruiting now · Not applicable · 1 countries · Registry ID NCT05783765

Recruiting nowNot applicableInterventional

What this study is about

A genetic risk for obesity does not always translate to the development of obesity among children, which points to the presence of risk-modifying factors that likely relate to energy balance behaviors as key behavioral drivers. Using an integrated approach to comprehensively examine the interplay between genotype and phenotype, this study will systematically assess the extent to which energy balance behaviors, alone or in combination, in conjunction with family-level influences can modify behavioral and genetic predispositions to childhood obesity in a high-risk sample of predominantly minority children from low-resource backgrounds. Identifying protective factors that may mitigate the impact of obesity risk on weight and adiposity outcomes is critical for moving the prevention of childhood obesity into a new direction.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age5 Years to 7 Years

SexAll

Healthy volunteersAccepted

ConditionObesity, Childhood

Full registry criteria

Inclusion Criteria: * Healthy children * Children ages 5-7 years * Children with BMI equal to or greater 5th percentile * Mother must be children's biological mother and primary caregiver * Mother must be able to read and understand English Exclusion Criteria: * Children with serious medical conditions or medication use known to affect food intake, body weight, physical activity, or sleep * Children with developmental and/or psychiatric conditions that may impact study compliance * Children with food allergies related to study foods or lactose intolerance * Children with low preference for study foods

Treatments and study arms

Heightened Drive to Eat

Behavioral

Participants' eating rate and eating in the absence of hunger will be assessed during a videotaped experimental meal. The relative reinforcing value of food will be assessed using a computerized behavioral choice task.

Primary outcomes

Body Mass Index (BMI)Change from baseline to 1-year follow-up

BMI z-score

Waist circumferenceChange from baseline to 1-year follow-up

Abdominal waist circumference (cm)

Body fatChange from baseline to 1-year follow-up

Body fat percentage

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Penn Medicine Center for Weight and Eating Disorders🇺🇸 Philadelphia, Pennsylvania, United States

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Ana CoronadoContact

Tanja VE Kral, PhDPrincipal Investigator