Clinical trial

Hedonic and Homeostatic Appetite Control in Obesity and Type 2 Diabetes in the Context of Meal and Exercise Timing

Active, not recruiting · Not applicable · 1 countries · Registry ID NCT05768958

Active, not recruitingNot applicableInterventional

What this study is about

The overall aim is to investigate effects of acute exercise on ad libitum energy intake and study whether this differs between morning and evening in individuals with overweight/obesity with or without type 2 diabetes (T2D). Furthermore, the aim is to examine the role of hedonic and homeostatic drivers of appetite control in obesity and T2D in the context of meal and exercise timing.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 75 Years

SexAll

Healthy volunteersAccepted

ConditionOverweight and Obesity, Type 2 Diabetes

Full registry criteria

Inclusion Criteria: * Adults with overweight or obesity (BMI \>25 kg/m2) with and without T2D * HbA1c ≥48 mmol/mol for people with T2D Exclusion Criteria: * Not able to eat ad libitum meal * Not able to perform the exercise bout * Daily smoking * For women: Pregnancy / planned pregnancy (within the study period) / lactating * Self-reported history of an eating disorder in the past 3 years * Self-reported weight change (\>5 kg) within three months prior to inclusion * Treatment with antidepressants * Treatment with fast acting insulin, combination insulin products and sulfonylureas * Alcohol/drug abuse or in treatment with disulfiram (antabus) at time of inclusion * Uncontrolled medical issues including but not limited to cardiovascular pulmonary, rheumatologic, hematologic, oncologic, infectious, gastrointestinal, or psychiatric disease; diabetes or other endocrine disease; immunosuppression * Current treatment with medication which significantly affect appetite or energy balance (e.g., GLP-1 receptor agonists) * Bariatric surgery * Unable to understand the informed consent and the study procedures * Concomitant participation in intervention studies * Incapable of understanding Danish

Treatments and study arms

Exercise

Other

45 min exercise bout performed on bicycle ergometer. The exercise bout will consist of a 10 min warm-up period at 40 % Watt max followed by 4 cycles of 4 min at 85 % Watt max and 3 min at 50 % Watt max. A cool-down period (7 min) will be performed at 40 % Watt max.

Control

Other

45 min rest during the same time period as the exercise bout on exercise study visits.

Primary outcomes

Ad libitum energy intake (KJ) after exercise compared with restMeasured after meal consumption at t = 30 minutes

Food intake (KJ) is measured after meal completion, exercise compared with rest

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Steno Diabetes Center Copenhagen🇩🇰 Herlev, Denmark

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