Active, not recruitingNot applicableObservational
What this study is about
This study evaluates the relationship between weight loss, circulating inflammatory markers and lipids from 24 patients before and after 6 months of pharmacotherapy as a standard of care for anti-obesity treatment
A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.
Basic eligibility
Age35 Years to 60 Years
SexAll
Healthy volunteersNot listed
ConditionObesity
Full registry criteria
Inclusion Criteria: * Body mass index (BMI): over 30 kg/m2 * Age: 35 to 60 years old Exclusion Criteria: * Taking medications with anti-inflammatory properties like glucocorticoids, prednisone, or non-steroidal anti-inflammatory medications, such as aspirin or Motrin Subjects on medications for long-term weight management such as phentermine-topiramate (Qsymia), orlistat (Xenical), naltrexone-bupropion (Contrave), and the glucagon-like peptide-1 receptor agonists such as liraglutide (Saxenda), and semaglutide (Wegovy). * Prior history of cancer * Having any clinical symptoms of systemic inflammation, acute infections such as Coronavirus disease 2019, or chronic diseases such as cancer, tuberculosis, autoimmune disease, and AIDS * An adult unable to consent * Prisoner * Pregnancy or breastfeeding women
Treatments and study arms
Semaglutide
Drug
Medication for weight loss
Phentermine-Topiramate combination
Drug
Medication for weight loss
Phentermine
Drug
Medication for weight loss
Tirzepatide
Drug
Medication for weight loss
Topiramate
Drug
Medication for weight loss
Diethylpropion
Drug
Medication for weight loss
Naltrexone/Bupropion
Drug
Medication for weight loss
Liraglutide
Drug
Medication for weight loss
Primary outcomes
weight lossbaseline and 24 weeksWeight Loss Percentage (Pounds lost divided by starting weight (in pounds) multiplied by 100)
MDSC in peripheral bloodbaseline and 24 weeksChanges in number of MDSC in blood
Levels of lipids in circulationbaseline and 24 weeksChanges in concentration (mg/dL) of each type of lipids: LDL-Cholesterol, triglycerides, and free fatty acids
